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The Early Treatment Phase in Parkinson's Disease: Not a Honeymoon for All, Not a Honeymoon at All?帕金森病的早期治疗阶段:并非所有人的蜜月,根本就不是蜜月?
J Parkinsons Dis. 2023;13(3):323-328. doi: 10.3233/JPD-225064.
2
Dopaminergic substitution in Parkinson's disease.帕金森病中的多巴胺能替代疗法。
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3
Dysphagia in Parkinson's disease is responsive to levodopa.帕金森病伴发的吞咽困难对左旋多巴治疗反应良好。
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4
Levodopa-related wearing-off in Parkinson's disease: identification and management.帕金森病中与左旋多巴相关的剂末现象:识别与管理
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When do levodopa motor fluctuations first appear in Parkinson's disease?左旋多巴运动波动在帕金森病中何时首次出现?
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Longitudinal qualitative assessment of meaningful symptoms and relevance of WATCH-PD digital measures for people with early Parkinson's.对早期帕金森病患者有意义症状的纵向定性评估以及WATCH-PD数字测量的相关性。
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本文引用的文献

1
Mechanisms of peripheral levodopa resistance in Parkinson's disease.帕金森病外周左旋多巴抵抗的机制
NPJ Parkinsons Dis. 2022 May 11;8(1):56. doi: 10.1038/s41531-022-00321-y.
2
Early Parkinson's Disease Phenotypes Tailored by Personality, Behavior, and Motor Symptoms.早期帕金森病表型可通过个性、行为和运动症状进行定制。
J Parkinsons Dis. 2022;12(5):1665-1676. doi: 10.3233/JPD-213070.
3
The silver linings of Parkinson's disease.帕金森病的一线希望。
NPJ Parkinsons Dis. 2022 Mar 3;8(1):21. doi: 10.1038/s41531-022-00283-1.
4
Parkinson's disease.帕金森病。
Lancet. 2021 Jun 12;397(10291):2284-2303. doi: 10.1016/S0140-6736(21)00218-X. Epub 2021 Apr 10.
5
A randomized controlled double-blind study of rotigotine on neuropsychiatric symptoms in de novo PD.罗替戈汀治疗新发帕金森病神经精神症状的随机对照双盲研究
NPJ Parkinsons Dis. 2020 Dec 15;6(1):41. doi: 10.1038/s41531-020-00142-x.
6
Is Levodopa Response a Valid Indicator of Parkinson's Disease?左旋多巴反应是否能有效指示帕金森病?
Mov Disord. 2021 Apr;36(4):948-954. doi: 10.1002/mds.28406. Epub 2020 Nov 30.
7
Time for a New Image of Parkinson Disease.帕金森病新形象的时机已到。
JAMA Neurol. 2020 Nov 1;77(11):1345-1346. doi: 10.1001/jamaneurol.2020.2412.
8
Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease.帕金森病中的多巴胺反应性和多巴胺抵抗性静止性震颤。
Neurology. 2020 Sep 15;95(11):e1461-e1470. doi: 10.1212/WNL.0000000000010316. Epub 2020 Jul 10.
9
Freezing of Gait and Its Levodopa Paradox.冻结步态及其左旋多巴悖论。
JAMA Neurol. 2020 Mar 1;77(3):287-288. doi: 10.1001/jamaneurol.2019.4006.
10
Should We Incorporate the Work of Elisabeth Kübler-Ross in Our Current Teaching and Practice and, If So, How?我们是否应该将伊丽莎白·库伯勒-罗斯的著作纳入当前的教学与实践中?如果是,该如何纳入?
Omega (Westport). 2021 Sep;83(4):706-728. doi: 10.1177/0030222819865397. Epub 2019 Jul 31.

帕金森病的早期治疗阶段:并非所有人的蜜月,根本就不是蜜月?

The Early Treatment Phase in Parkinson's Disease: Not a Honeymoon for All, Not a Honeymoon at All?

机构信息

Movement Disorders Unit, Neurology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Faculty of Medicine, Universidad de Alcalá, Alcalá de Henares, Spain.

出版信息

J Parkinsons Dis. 2023;13(3):323-328. doi: 10.3233/JPD-225064.

DOI:10.3233/JPD-225064
PMID:36847018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10200180/
Abstract

The discovery of levodopa in the late 60 s of twentieth century was a 'golden moment' for people with Parkinson's disease (PD). Unfortunately, clinical experience showed that some symptoms escaped from symptomatic control, and long-term complications developed. Back then, neurologists coined the term "honeymoon period" for the early phase of uncomplicated response to levodopa, and it continues to be used in scientific literature. However, medical terms are no longer restricted to professionals, and few people with PD relate to the notion of a "honeymoon". We examine the reasons why this term, once helpful, but inaccurate and inappropriate, should be abandoned.

摘要

20 世纪 60 年代末期左旋多巴的发现,是帕金森病(PD)患者的“黄金时刻”。不幸的是,临床经验表明,一些症状无法通过症状控制得到缓解,而且长期并发症也会出现。当时,神经科医生创造了“蜜月期”一词,用于描述左旋多巴治疗初期未出现并发症的阶段,该术语在科学文献中沿用至今。然而,医学术语不再仅限于专业人士使用,很少有 PD 患者认同“蜜月期”的概念。我们探讨了这个术语曾经有帮助,但现在既不准确也不恰当,应该被摒弃的原因。