59622Institute of Sound and Vibration Research, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
Interacoustics Research Unit, Technical University of Denmark, Lyngby, Denmark.
Trends Hear. 2023 Jan-Dec;27:23312165231154035. doi: 10.1177/23312165231154035.
The cortical auditory evoked potential (CAEP) is a change in neural activity in response to sound, and is of interest for audiological assessment of infants, especially those who use hearing aids. Within this population, CAEP waveforms are known to vary substantially across individuals, which makes detecting the CAEP through visual inspection a challenging task. It also means that some of the best automated CAEP detection methods used in adults are probably not suitable for this population. This study therefore evaluates and optimizes the performance of new and existing methods for aided (i.e., the stimuli are presented through subjects' hearing aid(s)) CAEP detection in infants with hearing loss. Methods include the conventional Hotellings T test, various modified q-sample statistics, and two novel variants of T statistics, which were designed to exploit the correlation structure underlying the data. Various additional methods from the literature were also evaluated, including the previously best-performing methods for adult CAEP detection. Data for the assessment consisted of aided CAEPs recorded from 59 infant hearing aid users with mild to profound bilateral hearing loss, and simulated signals. The highest test sensitivities were observed for the modified T statistics, followed by the modified q-sample statistics, and lastly by the conventional Hotelling's T test, which showed low detection rates for ensemble sizes <80 epochs. The high test sensitivities at small ensemble sizes observed for the modified T and q-sample statistics are especially relevant for infant testing, as the time available for data collection tends to be limited in this population.
皮质听觉诱发电位（CAEP）是对声音的神经活动变化，对于婴儿的听力学评估很有意义，尤其是那些使用助听器的婴儿。在这一人群中，CAEP 波形在个体之间存在很大差异，这使得通过目视检查来检测 CAEP 成为一项具有挑战性的任务。这也意味着一些在成人中使用的最佳自动 CAEP 检测方法可能不适合这一人群。因此，本研究评估和优化了新的和现有的用于听力损失婴儿辅助（即刺激通过受试者的助听器呈现）CAEP 检测的方法的性能。方法包括传统的 Hotellings T 检验、各种修改的 q 样本统计量以及两种新的 T 统计量变体，旨在利用数据的相关结构。还评估了文献中的各种其他方法，包括用于成人 CAEP 检测的先前表现最好的方法。评估数据包括 59 名轻度至重度双侧听力损失的婴儿助听器使用者的辅助 CAEPs 记录和模拟信号。对于集合大小<80 个时，修改后的 T 统计量表现出最高的测试灵敏度，其次是修改后的 q 样本统计量，而传统的 Hotelling's T 检验的检测率最低。在小集合大小下观察到的修改后的 T 和 q 样本统计量的高测试灵敏度尤其适用于婴儿测试，因为在这一人群中，数据收集的可用时间往往有限。
