Association between polymorphisms of the gene and allergic rhinitis risk in the Chinese population: a case-control study.

BACKGROUND

Allergic rhinitis (AR) is a great risk factor for developing asthma, and its pathogenesis is affected by various factors, such as gene and environment. is related to allergic diseases. Our purpose is to explore the correlation of single nucleotide polymorphisms (SNPs) in and AR risk in the Chinese population.

METHODS

We performed a case-control study including 1005 cases and 1004 controls. Rs2305479, rs4795400, and rs12450091 in were geneotyped using Agena MassARRAY. The relationships between SNPs and AR risk were assessed by logistic regression analysis in PLINK1.9.

RESULTS

Our study showed that rs4795400 was a protective factor for AR in overall (TT vs. CC: OR = 0.66,  = 0.009; TT vs. CC/TC: OR = 0.67,  = 0.008; additive: OR = 0.87,  = 0.042 males, people with BMI ≤ 24, and living in wind-blown sand area. Rs2305479 was associated with a reduced AR risk in males (TT vs. CC: OR = 0.47,  = 0.014; TT vs. CC/TC: OR = 0.43,  = 0.004). However, rs12450091 was a risk factor for AR in people living in the loess hilly region (CC: OR = 4.75,  = 0.047). The levels of EO and EO_per in the case group were significantly higher than those in the control group ( < 0.05).

CONCLUSION

This study indicated that polymorphisms (rs4795400, rs2305479, and rs12450091) were associated with AR susceptibility. Further studies are required to confirm our findings and to clarify the functional relationship.