Department of Obstetrics and Gynecology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100730, China.
School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
Chin Med J (Engl). 2023 Feb 5;136(3):295-304. doi: 10.1097/CM9.0000000000002170.
Estrogen impacts neural development; meanwhile, it has a protective effect on the brain. Bisphenols, primarily bisphenol A (BPA), can exert estrogen-like or estrogen-interfering effects by binding with estrogen receptors. Extensive studies have suggested that neurobehavioral problems, such as anxiety and depression, can be caused by exposure to BPA during neural development. Increasing attention has been paid to the effects on learning and memory of BPA exposure at different developmental stages and in adulthood. Further research is required to elucidate whether BPA increases the risk of neurodegenerative diseases and the underlying mechanisms, as well as to assess whether BPA analogs, such as bisphenol S and bisphenol F, influence the nervous system.
雌激素会影响神经发育；同时，它对大脑具有保护作用。双酚类物质主要是双酚 A（BPA），可以通过与雌激素受体结合发挥类雌激素或干扰雌激素的作用。大量研究表明，神经发育过程中接触 BPA 会导致神经行为问题，如焦虑和抑郁。人们越来越关注 BPA 在不同发育阶段和成年期暴露对学习和记忆的影响。需要进一步研究以阐明 BPA 是否会增加神经退行性疾病的风险及其潜在机制，以及评估 BPA 类似物，如双酚 S 和双酚 F 是否会影响神经系统。
