Waller P C, Cameron H A, Ramsay L E
University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, UK.
Postgrad Med J. 1987 Apr;63(738):305-7. doi: 10.1136/pgmj.63.738.305.
Two patients developed profound hypotension approximately one hour after taking an initial oral dose of ketanserin 40 mg. The reaction appeared similar to that reported with prazosin, and may have been due to the alpha 1-adrenoceptor antagonist action of ketanserin. Both patients were taking regular beta-blocker therapy, which may exacerbate such a reaction.
两名患者在首次口服40毫克酮色林后约一小时出现严重低血压。该反应与哌唑嗪报道的反应相似,可能是由于酮色林的α1-肾上腺素能受体拮抗作用所致。两名患者均接受常规β受体阻滞剂治疗,这可能会加重此类反应。