Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, China.
Department of Chemistry, Texas A&M University, College Station, TX, USA.
Nat Protoc. 2023 May;18(5):1621-1640. doi: 10.1038/s41596-023-00810-1. Epub 2023 Feb 27.
Luminescent sensing materials are attractive for environmental analysis due to their potential for high selectivity, excellent sensitivity and rapid (even instantaneous) response towards targeted analytes in diverse sample matrices. Many types of analytes have been detected in samples of wastewater for environmental protection, reagents and products in industrial production of drugs and pesticides, and biological markers in blood and urine for early diagnosis. It is still challenging, however, to develop appropriate materials with optimal sensing function for a targeted analyte. Here we synthesize metal-organic frameworks (MOFs) bearing multiple luminescent centers, such as metal cations (for example, Eu and Tb), organic ligands and guests, which are chosen for optimal selectivity for the analytes of interest, including industrial synthetic intermediates and chiral drugs. Interaction between the metal node, ligand, guest and analyte results in a complex system with different luminescence properties compared with the porous MOF on its own. The operation time for the synthesis is usually less than 4 h; the quick screening for sensitivity and selectivity takes ~0.5 h and includes steps to optimize the energy levels and spectrum parameters. It can be used to accelerate the discovery of advanced sensing materials for practical applications.
发光传感材料因其对目标分析物在各种样品基质中具有高选择性、优异的灵敏度和快速（甚至瞬时）响应的潜力，而在环境分析中具有吸引力。已经在用于环境保护的废水样品、药物和农药工业生产中的试剂和产品以及用于早期诊断的血液和尿液中的生物标志物中检测到许多类型的分析物。然而，开发针对目标分析物具有最佳传感功能的合适材料仍然具有挑战性。在这里，我们合成了具有多个发光中心的金属-有机框架（MOFs），例如金属阳离子（例如 Eu 和 Tb）、有机配体和客体，它们是针对感兴趣的分析物（包括工业合成中间体和手性药物）的最佳选择性而选择的。金属节点、配体、客体和分析物之间的相互作用导致具有与多孔 MOF 本身不同的发光性质的复杂体系。合成的操作时间通常少于 4 小时；灵敏度和选择性的快速筛选需要大约 0.5 小时，包括优化能级和光谱参数的步骤。它可以用于加速实际应用中先进传感材料的发现。
