Rabia Eliskander, Tuga Beza, Ondarza José de, Ramos Saleen M, Lam Edmond, Hrapovic Sabahudin, Liu Yali, Sunasee Rajesh
Department of Chemistry and Biochemistry, State University of New York at Plattsburgh, Plattsburgh, NY 12901, USA.
Department of Biological Sciences, State University of New York at Plattsburgh, Plattsburgh, NY 12901, USA.
Polymers (Basel). 2023 Feb 9;15(4):865. doi: 10.3390/polym15040865.
Cationic nanomaterials are promising candidates for the development of effective antibacterial agents by taking advantage of the nanoscale effects as well as other exceptional physicochemical properties of nanomaterials. In this study, carboxylated cellulose nanocrystals (cCNCs) derived from softwood pulp were coated with cationic poly(diallyldimethylammonium chloride) of varying molecular weights. The resulting cationic carboxylated cellulose nanocrystals coated with poly(diallyldimethylammonium chloride) (cCNCs-PDDA) nanomaterials were characterized for their structural and morphological properties using Fourier transform infrared spectroscopy, dynamic light scattering, zeta potential, elemental analysis, transmission electron microscopy, and thermogravimetric analysis. Cationic cCNCs-PDDA were investigated for their antibacterial properties against Gram-positive and Gram-negative and using a bacterial lawn growth inhibition assay. cCNC-PDDA materials displayed marked antibacterial activity, particularly against Gram-positive . Overall, our results indicated that cCNCs-PDDA could be a potential candidate for antibacterial applications such as antibacterial surfaces or coatings.
阳离子纳米材料利用纳米尺度效应以及纳米材料的其他特殊物理化学性质，有望成为开发有效抗菌剂的候选材料。在本研究中，将源自软木浆的羧化纤维素纳米晶体（cCNCs）用不同分子量的阳离子聚二烯丙基二甲基氯化铵进行包覆。使用傅里叶变换红外光谱、动态光散射、zeta电位、元素分析、透射电子显微镜和热重分析对所得的包覆有聚二烯丙基二甲基氯化铵的阳离子羧化纤维素纳米晶体（cCNCs-PDDA）纳米材料的结构和形态特性进行了表征。使用细菌菌苔生长抑制试验研究了阳离子cCNCs-PDDA对革兰氏阳性菌和革兰氏阴性菌的抗菌性能。cCNC-PDDA材料表现出显著的抗菌活性，尤其是对革兰氏阳性菌。总体而言，我们的结果表明，cCNCs-PDDA可能是抗菌表面或涂层等抗菌应用的潜在候选材料。
