Visalli Giuseppa, Laganà Antonio, Lo Giudice Daniela, Calimeri Sebastiano, Caccamo Daniela, Trainito Alessandra, Di Pietro Angela, Facciolà Alessio
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Istituto Clinico Polispecialistico C.O.T. Cure Ortopediche Traumatologiche S.p.A., 98124 Messina, Italy.
Vaccines (Basel). 2023 Jan 18;11(2):217. doi: 10.3390/vaccines11020217.
The COVID-19 pandemic has hugely impacted many different aspects of human health, and vaccination is one of the most effective weapons to manage it. However, many different factors, such as age, gender, comorbidities and lifestyles, play a role in the response to infections and vaccines. We carried out this study to evaluate the potential role played by some individual factors in the production of anti-COVID-19 antibodies in the light of personalized and future vaccinology. We conducted an observational study consisting of a retrospective phase, exploiting previous data about anti-COVID-19 antibody responses, with a prospective phase to investigate individual variables through the use of a questionnaire. The antibody response after the COVID-19 vaccination was inversely related to old age, increased BMI and the number of smoking years, while a positive correlation was found with moderate alcohol consumption and especially with circulating levels of vitamin D, as clearly shown by the multivariate regression analysis. Our study showed that a number of variables are involved in the COVID-19 vaccine antibody response. These findings are very important and can be considered in the light of a future and personalized vaccinology.
新冠疫情对人类健康的诸多方面产生了巨大影响，而接种疫苗是应对疫情最有效的武器之一。然而，年龄、性别、合并症和生活方式等多种不同因素在对感染和疫苗的反应中发挥着作用。鉴于个性化和未来疫苗学，我们开展了这项研究，以评估某些个体因素在抗新冠病毒抗体产生中所起的潜在作用。我们进行了一项观察性研究，包括一个回顾性阶段，利用先前关于抗新冠病毒抗体反应的数据，以及一个前瞻性阶段，通过使用问卷来调查个体变量。新冠疫苗接种后的抗体反应与老年、体重指数增加和吸烟年限呈负相关，而与适度饮酒尤其是与维生素D的循环水平呈正相关，多元回归分析清楚地表明了这一点。我们的研究表明，许多变量都与新冠疫苗抗体反应有关。这些发现非常重要，可从未来个性化疫苗学的角度加以考虑。
