Langhans W, Duss M, Scharrer E
Institut für Veterinär-Physiologie der Universität Zürich, Switzerland.
Physiol Behav. 1987;41(1):31-5. doi: 10.1016/0031-9384(87)90127-2.
The effects of intraperitoneally injected pancreatic glucagon on feeding and on plasma levels of pancreatic glucagon as well as on blood glucose levels and liver glycogen content were investigated in rats, in order to test the physiological relevance of exogenous glucagon's satiety effect. The rats were intraperitoneally injected with various doses of glucagon [60, 240 or 480 micrograms/kg body weight (b.wt.)] or vehicle when they started to eat after a 12 hr period of food deprivation. Only the highest dose of pancreatic glucagon (480 micrograms/kg b.wt.) decreased the size and duration of the first meal after injection. Hepatic vein, hepatic portal vein and aortal plasma pancreatic glucagon levels were increased about 10 fold by 60 and 240 micrograms/kg b.wt. of glucagon and about 30 to 70 fold by 480 micrograms/kg b.wt. of glucagon. All glucagon doses reduced liver glycogen content and increased hepatic vein blood glucose levels similarly. The results indicate that decreased feeding after intraperitoneal injection of glucagon is a pharmacological effect of the hormone, at least under the conditions tested.
为了检验外源性胰高血糖素饱腹感效应的生理相关性，研究人员对大鼠进行了实验，观察腹腔注射胰高血糖素对进食、血浆胰高血糖素水平、血糖水平以及肝糖原含量的影响。在禁食12小时后开始进食时，给大鼠腹腔注射不同剂量的胰高血糖素[60、240或480微克/千克体重（b.wt.）]或赋形剂。只有最高剂量的胰高血糖素（480微克/千克b.wt.）能减小注射后第一餐的食量并缩短用餐时间。60和240微克/千克b.wt.的胰高血糖素可使肝静脉、肝门静脉和主动脉血浆中的胰高血糖素水平升高约10倍，而480微克/千克b.wt.的胰高血糖素可使其升高约30至70倍。所有剂量的胰高血糖素均能类似地降低肝糖原含量并提高肝静脉血糖水平。结果表明，至少在所测试的条件下，腹腔注射胰高血糖素后进食减少是该激素的药理作用。
