Geary N, Langhans W, Scharrer E
Am J Physiol. 1981 Nov;241(5):R330-5. doi: 10.1152/ajpregu.1981.241.5.R330.
The suppression of food intake elicited in rats by injection of pancreatic glucagon and the accompanying changes in energy metabolite flux were investigated. Glucagon injections, 120-360 micrograms ip, were made as rats began the first meal of the dark phase after food deprivation during the light phase. Glucagon-injected rats terminated their meals sooner and ate smaller meals than vehicle-injected rats. For metabolic assays, rats were identically treated and killed just at meal onset or 15 min later. Portal vein blood glucose increased similarly in all rats allowed to feed, whereas plasma nonesterified fatty acid and D-(-)-3-hydroxybutyrate levels decreased during feeding. In contrast, hepatic vein and aorta blood glucose levels increased more after glucagon than after vehicle injections. Liver glycogen content decreased after glucagon injections. The highest glucagon dose only had slight lipolytic and ketogenic effects. It was concluded the glycogenolytic and hyperglycemic action of glucagon may generate a satiety signal sufficient to cause premature termination of meals. Changes in ketone and lipid fluxes do not appear necessary for this behavioral effect.
研究了注射胰高血糖素对大鼠食物摄入量的抑制作用以及伴随的能量代谢物通量变化。在光照期禁食后，当大鼠开始黑暗期的第一餐时，腹腔注射120 - 360微克胰高血糖素。注射胰高血糖素的大鼠比注射赋形剂的大鼠更早结束进食且进食量更小。为进行代谢分析，对大鼠进行相同处理，并在进食开始时或15分钟后处死。所有进食的大鼠门静脉血糖升高情况相似，而进食期间血浆非酯化脂肪酸和D -（-）-3 - 羟基丁酸水平下降。相比之下，注射胰高血糖素后肝静脉和主动脉血糖水平升高幅度大于注射赋形剂后。注射胰高血糖素后肝糖原含量降低。最高剂量的胰高血糖素仅有轻微的脂解和生酮作用。得出的结论是，胰高血糖素的糖原分解和高血糖作用可能产生足以导致进食过早终止的饱腹感信号。酮和脂质通量的变化对于这种行为效应似乎并非必要。
