米佐那宾抗口蹄疫病毒的体外和体内抗病毒活性。
In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus.
机构信息
State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China.
出版信息
Molecules. 2019 May 3;24(9):1723. doi: 10.3390/molecules24091723.
Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals, which has significant economic consequences in affected countries. As the currently available vaccines against FMD provide no protection until 4-7 days post-vaccination, the only alternative method to control the spread of FMD virus (FMDV) during outbreaks is the application of antiviral agents. Hence, it is important to identify effective antiviral agents against FMDV infection. In this study, we found that mizoribine has potent antiviral activity against FMDV replication in IBRS-2 cells. A time-of-drug-addition assay demonstrated that mizoribine functions at the early stage of replication. Moreover, mizoribine also showed antiviral effect on FMDV in vivo. In summary, these results revealed that mizoribine could be a potential antiviral drug against FMDV.
口蹄疫（FMD）是一种具有高度传染性的偶蹄动物病毒病，在受影响的国家会造成重大的经济后果。由于目前可用的 FMD 疫苗在接种后 4-7 天内无法提供保护，因此在疫情爆发期间控制 FMD 病毒（FMDV）传播的唯一替代方法是应用抗病毒药物。因此，寻找针对 FMDV 感染的有效抗病毒药物非常重要。在这项研究中，我们发现，咪鲜胺对 IBRS-2 细胞中的 FMDV 复制具有很强的抗病毒活性。药物添加时间测定表明，咪鲜胺在复制的早期阶段发挥作用。此外，咪鲜胺对体内 FMDV 也表现出抗病毒作用。总之，这些结果表明咪鲜胺可能是一种针对 FMDV 的潜在抗病毒药物。
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