Holborow E J
Methods Achiev Exp Pathol. 1979;9:244-60.
Smooth muscle antoantibodies are found in high titre in some patients with chronic active hepatitis, and in lower titres in a number of other liver diseases and certain viral infections. They are directed at contractile proteins of the actomyosin group, and anti-actin activity appears to predominate. Whether occurring in disease affecting the liver or in other conditions, smooth muscle antibody production is thought to be stimulated when contractile proteins of non-muscle cells become immunogenic as a result of changes induced in the cells by viral infection or by other unknown causes of derangement of cytoskeletal structure.
在一些慢性活动性肝炎患者中可发现高滴度的平滑肌自身抗体，而在其他一些肝脏疾病及某些病毒感染中其滴度较低。这些抗体针对的是肌动球蛋白组的收缩蛋白，且抗肌动蛋白活性似乎占主导。无论平滑肌抗体产生于影响肝脏的疾病还是其他情况，当非肌肉细胞的收缩蛋白因病毒感染或细胞骨架结构紊乱的其他未知原因在细胞内引起变化而具有免疫原性时，就会刺激平滑肌抗体的产生。
