Agrawal Rutvi, Garg Akash, Deshmukh Rohitas
Rajiv Academy for Pharmacy, NH-2, Mathura-Delhi Road, P.O. Chhatikara, Mathura, 281001, U.P. India.
Institute of Pharmaceutical Research (IPR), GLA University, NH-2, Mathura-Delhi Road, Chaumuhan, Mathura, 281406, U.P. India.
Curr Pharm Des. 2023;29(8):604-619. doi: 10.2174/1381612829666230228115442.
3D printing in other fields, such as aviation, is quite old, but in the pharmaceutical area, it is an emerging technique. 3D printing is used to formulate various drug delivery systems and dosage forms with complex geometry. It allows large and fast production of products according to the need of the patient. Today, it is the widely used manufacturing technique in the healthcare field for the engineering of tissues and tissue models, production of medicines and medical devices, organ and tissue bioprinting, implant manufacturing, and production of polypills, vaginal rings, orodispersible films, etc. It allows the production of various dosage forms with complex release profiles containing multiple active ingredients. It is used for manufacturing medicines according to the need of individual patients focusing on the concept of personalized medicines. The idea of customized medicines allows change of dosage and design of the product as per individual and with decreased side effects. This review details various techniques of 3D printing used, such as stereolithography, fused deposition modeling, inkjet printing, etc., and applications and dosage forms developed with the latest patents. The significant challenges in the emergence of the 3D printing technique are the involvement of complex combinations to achieve desired properties, and also, the bioprinter involved provides slow and less resolution. The materials prepared by this technique are both biocompatible and printable, due to which additive manufacturing is increasing in the field of medicine.
3D打印在航空等其他领域已经相当成熟，但在制药领域却是一项新兴技术。3D打印用于制备各种具有复杂几何形状的药物递送系统和剂型。它能够根据患者需求大量快速生产产品。如今，它是医疗保健领域广泛应用的制造技术，用于组织和组织模型的工程设计、药品和医疗器械的生产、器官和组织生物打印、植入物制造以及多片复方制剂、阴道环、口腔崩解片等的生产。它能够生产具有包含多种活性成分的复杂释放曲线的各种剂型。它用于根据个体患者需求制造药物，专注于个性化药物的概念。定制药物的理念允许根据个体情况改变剂量和产品设计，并减少副作用。这篇综述详细介绍了所使用的各种3D打印技术，如立体光刻、熔融沉积建模、喷墨打印等，以及利用最新专利开发的应用和剂型。3D打印技术出现的重大挑战包括需要复杂组合才能实现所需性能，而且所涉及的生物打印机速度慢且分辨率低。通过该技术制备的材料兼具生物相容性和可打印性，正因如此，增材制造在医学领域的应用日益增加。
