de Oliveira Jaqueline Vaz, Oliveira da Rocha Márcia Cristina, de Sousa-Junior Ailton Antônio, Rodrigues Mosar Corrêa, Farias Gabriel Ribeiro, da Silva Patrícia Bento, Bao Sônia Nair, Bakuzis Andris Figueiroa, Azevedo Ricardo Bentes, Morais Paulo César, Muehlmann Luís Alexandre, Figueiró Longo João Paulo
Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil.
Institute of Physics, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil.
Nanomedicine (Lond). 2022 Nov;17(27):2073-2088. doi: 10.2217/nnm-2022-0176. Epub 2023 Feb 28.
Investigate the heterogeneous tumor tissue organization and examine how this condition can interfere with the passive delivery of a lipid nanoemulsion in two breast cancer preclinical models (4T1 and Ehrlich). The authors used image techniques to follow the nanoemulsion biodistribution and microtomography, as well as traditional histopathology and electron microscopy to evaluate the tumor structural characteristics. Lipid nanoemulsion was delivered to the tumor, vascular organization depends upon the subtumoral localization and this heterogeneous organization promotes a nanoemulsion biodistribution to the highly vascular peripherical region. Also, the results are presented with a comprehensive mathematical model, describing the differential biodistribution in two different breast cancer models, the 4T1 and Ehrlich models.
在两种乳腺癌临床前模型（4T1和艾氏腹水癌）中研究异质性肿瘤组织结构，并考察这种情况如何干扰脂质纳米乳剂的被动递送。作者使用成像技术追踪纳米乳剂的生物分布以及显微断层扫描，还运用传统组织病理学和电子显微镜来评估肿瘤的结构特征。脂质纳米乳剂被递送至肿瘤，血管组织取决于肿瘤下方的定位，这种异质性结构促使纳米乳剂在血管丰富的周边区域实现生物分布。此外，研究结果还通过一个综合数学模型呈现，该模型描述了4T1和艾氏腹水癌这两种不同乳腺癌模型中的差异生物分布。
