From the Department of Paediatrics, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton.
Centre for Health Analytics, Murdoch Children's Research Institute.
Pediatr Infect Dis J. 2023 Apr 1;42(4):276-280. doi: 10.1097/INF.0000000000003828. Epub 2023 Feb 8.
Beginning in early 2022, clusters of severe pediatric hepatitis were reported in Europe and the United States. To date, no cause has been identified although human adenovirus 41 has been proposed in a proportion of cases. We examined population data >11 years for hepatitis clusters in Victoria, Australia, and whether any were spatiotemporally associated with community transmission of common respiratory viruses.
We used SaTScan to analyze for clusters of pediatric hepatitis and respiratory adenoviruses in Victoria. Negative binomial regression analysis was performed to determine any associations between hepatitis and respiratory viruses across Victoria between July 1, 2011, and June 30, 2022.
A number of positive associations were observed in Victoria between pediatric hepatitis clusters and respiratory viruses in our spatiotemporal analysis. A positive association was not found with respiratory adenoviruses or SARS-CoV-2. Increased hepatitis clusters were observed in 2021 and 2022 as noted internationally.
The current hepatitis outbreak is novel and, although respiratory viruses are broadly associated with hepatitis, SARS-CoV-2 and respiratory adenoviruses are unlikely to be related.
自 2022 年初以来，欧洲和美国报告了几起因严重小儿肝炎聚集性病例。迄今为止，尽管在一部分病例中提出了人类腺病毒 41，但尚未确定病因。我们调查了澳大利亚维多利亚州超过 11 年的肝炎聚集性人群数据，以及是否有任何聚集性病例与常见呼吸道病毒的社区传播存在时空关联。
我们使用 SaTScan 分析维多利亚州小儿肝炎和呼吸道腺病毒的聚集情况。采用负二项回归分析方法，确定 2011 年 7 月 1 日至 2022 年 6 月 30 日期间维多利亚州肝炎与呼吸道病毒之间的任何关联。
在我们的时空分析中，维多利亚州的小儿肝炎聚集病例与呼吸道病毒之间观察到了许多阳性关联。呼吸道腺病毒或 SARS-CoV-2 与肝炎之间未发现阳性关联。与国际上的报道一致，2021 年和 2022 年观察到肝炎聚集病例增加。
目前的肝炎疫情是新颖的，尽管呼吸道病毒广泛与肝炎相关，但 SARS-CoV-2 和呼吸道腺病毒不太可能有关联。
