Lindroth Rickard, Materna Kelly L, Hammarström Leif, Wallentin Carl-Johan
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE41296, Sweden.
Department of Chemistry-Ångström Laboratories, Uppsala University, Box 523, Uppsala SE75120, Sweden.
ACS Org Inorg Au. 2022 Aug 2;2(5):427-432. doi: 10.1021/acsorginorgau.2c00024. eCollection 2022 Oct 5.
A heterogenized iridium catalyst was employed to perform photoredox catalysis for a collection of mechanistically orthogonal reactions using very low quantities of iridium (0.01-0.1 mol %). The heterogenized construct consists of an organometallic iridium coordination complex bonded to an aluminum metal oxide solid-state support via an anchoring group. The solid-state support allows for easy recovery and reusability of the catalyst. Evaluation of the catalytic activity was performed with five different reactions, showing broad applicability and demonstrating the general potential for a heterogenized strategy. Moreover, the heterogenized catalyst was shown to be reusable up to five times and also mediated the reactions with much higher efficiency than the original processes by employing the corresponding homogeneous catalyst. As a result of the low catalyst loadings employed, the feasibility of reusage, and faster reaction times, this catalyst offers a more sustainable option when precious metal catalysts are used in organic synthesis. Finally, the catalyst was successfully applied to a gram-scale reaction, showing it is susceptible to scalability.
一种异质化铱催化剂被用于进行光氧化还原催化，用于一系列机理正交反应，使用的铱量非常低（0.01 - 0.1 mol%）。这种异质化结构由一个有机金属铱配位络合物通过一个锚定基团键合到氧化铝金属氧化物固态载体上组成。固态载体使得催化剂易于回收和重复使用。通过五个不同的反应对催化活性进行了评估，显示出广泛的适用性，并证明了异质化策略的总体潜力。此外，这种异质化催化剂被证明可重复使用多达五次，并且通过使用相应的均相催化剂，其介导反应的效率比原始过程高得多。由于所使用的催化剂负载量低、可重复使用的可行性以及更快的反应时间，当在有机合成中使用贵金属催化剂时，这种催化剂提供了一种更具可持续性的选择。最后，该催化剂成功应用于克级反应，表明它易于扩大规模。
