Ashton H, Golding J F, Marsh V R, Thompson J W, Hassanyeh F, Tyrer S P
Department of Pharmacological Sciences, University of Newcastle-upon-Tyne.
Psychol Med. 1988 May;18(2):305-17. doi: 10.1017/s0033291700007856.
Relationships between clinical ratings and cortical evoked potentials were examined before and during antidepressant drug treatment in 32 patients with major depressive disorder (DSM-III). Clinical rating scales included Hamilton Rating Scale for Depression, Beck Depression Inventory, Present State Examination (PSE) and Newcastle Scale. Evoked potentials included contingent negative variation (CNV), post-imperative negative variation (PINV) and auditory evoked potential (AEP) There were close correlations between all rating scales, and factor analysis produced only one component, suggesting that the common variance between them related to severity of depression. CNV magnitude before treatment correlated negatively with severity of depression regardless of diagnostic category. Depressed patients had a prominent PINV which persisted during antidepressant treatment. The amplitude of late components (N1P2) of the AEP was reduced strikingly in patients with a history of suicide attempts.
在32例重度抑郁症（DSM-III）患者中，研究了抗抑郁药物治疗前及治疗期间临床评分与皮质诱发电位之间的关系。临床评分量表包括汉密尔顿抑郁量表、贝克抑郁量表、现状检查（PSE）和纽卡斯尔量表。诱发电位包括关联性负变（CNV）、指令后负变（PINV）和听觉诱发电位（AEP）。所有评分量表之间均存在密切相关性，因子分析仅产生一个成分，表明它们之间的共同方差与抑郁严重程度相关。无论诊断类别如何，治疗前CNV幅度与抑郁严重程度呈负相关。抑郁患者有明显的PINV，且在抗抑郁治疗期间持续存在。有自杀未遂史的患者，AEP的晚期成分（N1P2）振幅显著降低。
