Qian Yujing, Yang Jingyuan, Liang Anyi, Zhao Chan, Gao Fei, Zhang Meifen
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Med (Lausanne). 2021 Sep 16;8:698644. doi: 10.3389/fmed.2021.698644. eCollection 2021.
To investigate choroidal changes in patients with Vogt-Koyanagi-Harada disease (VKH) using widefield swept-source optical coherence tomography angiography (SS-OCTA). In this cross-sectional study, 133 eyes of 69 patients with VKH (52 eyes of 28 active VKH patients and 81 eyes of 41 inactive VKH patients) and 104 eyes of 52 age and sex matched healthy volunteers were imaged using a widefield SS-OCTA instrument. On 12 mm × 12 mm OCTA scans, mean choroidal thickness (MCT), choroidal vascularity index (CVI), choriocapillaris (CC) flow area, and mean retinal thickness (MRT) were separately calculated in the fovea (diameter of 1 mm) and in concentric rings with different radii (1-3, 3-6, 6-9, and 9-12 mm). Eyes with active VKH showed significant increases in MCT, CVI, and MRT, and decreased CC flow area in all central and peripheral regions (0-1, 1-3, 3-6, 6-9, and 9-12 mm) than in the healthy eyes ( ≤ 0.01) and inactive VKH eyes ( < 0.05). Inactive VKH eyes only showed marked decrease in CC flow area in all regions compared with controls ( < 0.05). Flow voids were observed in 51 of 52 (98.1%) active VKH eyes and 50 of 81 (61.7%) inactive VKH eyes on 12 mm × 12 mm OCTA. The MCT of all regions was significantly correlated with age, disease duration, and disease activity, whereas CVI was associated with age and disease activity. The CC flow void was related to visual acuity in all regions ( < 0.05). Widefield SS-OCTA enables a more comprehensive evaluation of chorioretinal changes in patients with VKH disease. Structural and vascular abnormalities are observed in both the central and peripheral choroid and are closely correlated with disease activity.
使用广角扫频源光学相干断层扫描血管造影（SS-OCTA）研究Vogt-小柳-原田病（VKH）患者的脉络膜变化。在这项横断面研究中，使用广角SS-OCTA仪器对69例VKH患者的133只眼（28例活动性VKH患者的52只眼和41例非活动性VKH患者的81只眼）以及52名年龄和性别匹配的健康志愿者的104只眼进行成像。在12 mm×12 mm的OCTA扫描上，分别计算黄斑中心凹（直径1 mm）以及不同半径（1 - 3、3 - 6、6 - 9和9 - 12 mm）的同心环区域的平均脉络膜厚度（MCT）、脉络膜血管指数（CVI）、脉络膜毛细血管（CC）血流面积和平均视网膜厚度（MRT）。活动性VKH患者的眼睛在所有中央和周边区域（0 - 1、1 - 3、3 - 6、6 - 9和9 - 12 mm）的MCT、CVI和MRT均显著增加，CC血流面积减少，与健康眼睛相比差异有统计学意义（≤0.01），与非活动性VKH眼睛相比差异有统计学意义（<0.05）。与对照组相比，非活动性VKH眼睛仅在所有区域的CC血流面积显著减少（<0.05）。在12 mm×12 mm的OCTA上，52只活动性VKH眼睛中的51只（98.1%）和81只非活动性VKH眼睛中的50只（61.7%）观察到血流信号缺失。所有区域的MCT与年龄、病程和疾病活动度显著相关，而CVI与年龄和疾病活动度相关。所有区域的CC血流信号缺失与视力相关（<0.05）。广角SS-OCTA能够更全面地评估VKH病患者的脉络膜视网膜变化。中央和周边脉络膜均观察到结构和血管异常，且与疾病活动度密切相关。
