Department of Nephrology, Kyoto City Hospital, 1-2 Mibu Higashitakadacho, Nakagyo-Ku, Kyoto-Shi, Kyoto-Fu, Kyoto, 604-8845, Japan.
CEN Case Rep. 2023 Nov;12(4):378-383. doi: 10.1007/s13730-023-00779-6. Epub 2023 Mar 1.
A 48-year-old woman presented with hyperreninemic hypertension and renal dysfunction and was diagnosed with hydronephrosis-related Page kidney. The pathophysiology was "renal tamponade", in which the kidney was compressed by the renal pelvis and Gerota's fascia, resulting in intrarenal microvascular ischemia. Ureteral stent placement promptly improved the hyperreninemic hypertension and renal dysfunction, and additional perirenal fluid drainage gradually improved these conditions. These observations indicated the following three points. First, renal compression-induced renin-angiotensin-aldosterone system upregulation plays an important role in the pathogenesis of Page kidney. Second, physicians should consider perirenal fluid drainage as a therapeutic option in addition to ureteral stenting in patients with hydronephrosis-related Page kidney. Third, bilateral perirenal subcapsular hematomas in this case could be caused by hydronephrosis. Hydronephrosis-induced intrarenal pressure elevation possibly caused chronic perirenal subcapsular hemorrhage at the vulnerable sites of the renal cortex and peeling of the renal capsule from the cortex, resulting in the bilateral massive subcapsular hematomas and Page kidney.
一位 48 岁女性因高肾素性高血压和肾功能障碍就诊,被诊断为与肾积水相关的 Page 肾。其病理生理学为“肾填塞”,即肾盂和肾筋膜压迫肾脏,导致肾内微血管缺血。输尿管支架置入术迅速改善了高肾素性高血压和肾功能障碍,而额外的肾周液引流逐渐改善了这些情况。这些观察结果表明了以下三点。首先,肾压迫引起的肾素-血管紧张素-醛固酮系统上调在 Page 肾的发病机制中起重要作用。其次,对于与肾积水相关的 Page 肾患者,除了输尿管支架置入术之外,医生还应考虑肾周液引流作为一种治疗选择。第三,本例双侧肾周包膜下血肿可能由肾积水引起。肾积水引起的肾内压力升高可能导致脆弱部位的肾皮质慢性肾周包膜下出血和肾包膜从皮质剥离,从而导致双侧大量包膜下血肿和 Page 肾。