Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland.
Department of Virology, University of Helsinki, Helsinki, Finland.
J Neurovirol. 2023 Apr;29(2):226-231. doi: 10.1007/s13365-023-01112-8. Epub 2023 Mar 1.
Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS.
前庭神经鞘瘤 (VS) 的病因尚不清楚。病毒可以在神经组织中潜伏数十年，并且新发现了具有未知致癌潜力的病毒。通过定量 PCR 分析了 46 例福尔马林固定石蜡包埋 VS 样本中的疱疹病毒、多瘤病毒、细小病毒和圆环病毒 DNA。对 5 个样本进行了靶向下一代测序分析。总共在 24/46（52%）肿瘤样本中检测到病毒 DNA，主要是圆环病毒（46%）。我们的研究结果表明，被认为是正常病毒组的圆环病毒在 VS 中经常持续存在。其他病毒均未广泛存在，因此提示其在 VS 中作用不大。
