Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cell. 2023 Apr 13;186(8):1670-1688. doi: 10.1016/j.cell.2023.01.038. Epub 2023 Feb 28.
The uptake and metabolism of nutrients support fundamental cellular process from bioenergetics to biomass production and cell fate regulation. While many studies of cell metabolism focus on cancer cells, the principles of metabolism elucidated in cancer cells apply to a wide range of mammalian cells. The goal of this review is to discuss how the field of cancer metabolism provides a framework for revealing principles of cell metabolism and for dissecting the metabolic networks that allow cells to meet their specific demands. Understanding context-specific metabolic preferences and liabilities will unlock new approaches to target cancer cells to improve patient care.
营养物质的摄取和代谢支持从生物能量学到生物量生产和细胞命运调控等基本细胞过程。虽然许多细胞代谢研究都集中在癌细胞上，但在癌细胞中阐明的代谢原理适用于广泛的哺乳动物细胞。本文的目的是讨论癌症代谢领域如何为揭示细胞代谢原理以及剖析允许细胞满足其特定需求的代谢网络提供框架。了解特定于背景的代谢偏好和缺陷将为靶向癌细胞以改善患者治疗提供新方法。
