Recent advances in exploiting carrageenans as a versatile functional material for promising biomedical applications.

Carrageenans are a group of biopolymers widely found in red seaweeds. Commercial carrageenans have been traditionally used as emulsifiers, stabilizers, and thickening and gelling agents in food products. Carrageenans are regarded as bioactive polysaccharides with disease-modifying and microbiota-modulating activities. Novel biomedical applications of carrageenans as biocompatible functional materials for fabricating hydrogels and nanostructures, including carbon dots, nanoparticles, and nanofibers, have been increasingly exploited. In this review, we describe the unique structural characteristics of carrageenans and their functional relevance. We summarize salient physicochemical features, including thixotropic and shear-thinning properties, of carrageenans. Recent results from clinical trials in which carrageenans were applied as both antiviral and antitumor agents and functional materials are discussed. We also highlight the most recent advances in the development of carrageenan-based targeted drug delivery systems with various pharmaceutical formulations. Promising applications of carrageenans as a bioink material for 3D printing in tissue engineering and regenerative medicine are systematically evaluated. We envisage some key hurdles and challenges in the commercialization of carrageenans as a versatile material for clinical practice. This comprehensive review of the intimate relationships among the structural features, unique rheological properties, and biofunctionality of carrageenans will provide novel insights into their biomedicine application potential.