Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu 600 119, India.
Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu 600 119, India.
Int J Biol Macromol. 2022 Jan 1;194:870-881. doi: 10.1016/j.ijbiomac.2021.11.142. Epub 2021 Nov 27.
Marine ecosystem associated organisms are an affluent source of bioactive compounds. Polysaccharides with unique structural and practical entities have gained special studies interest inside the current biomedical zone. Polysaccharides are the main components of marine algae, plants, animals, insects, and microorganisms. In recent times research on seaweed is more persistent for extraction of natural bioactive "Sulfated polysaccharides" (SPs). The considerable amount of SP exists in the algae in the form of fucans, fucoidans, carrageenans, ulvan, etc. Major function of SPs is to act as a defensive lattice towards the infective organism. All SPs possess the high potential and possess a broad range of therapeutic applications as antitumor, immunomodulatory, vaccine adjuvant, anti-inflammatory, anticoagulant, antiviral, antiprotozoal, antimicrobial, antilipemic, therapy of regenerative medicine, also in drug delivery and tissue engineering application. This review aims to discuss the biomedicine applications of sulfated polysaccharides from marine seaweeds.
海洋生态系统相关生物是生物活性化合物的丰富来源。具有独特结构和实用实体的多糖在当前的生物医学领域引起了特别的研究兴趣。多糖是海洋藻类、植物、动物、昆虫和微生物的主要成分。近年来,海藻的研究更多地集中在提取天然生物活性“硫酸多糖”(SPs)上。大量的 SP 以岩藻聚糖、褐藻胶、角叉菜聚糖、昆布多糖等形式存在于藻类中。SP 的主要功能是作为一种防御晶格来对抗感染性生物。所有的 SPs 都具有很高的潜力,并具有广泛的治疗应用,如抗肿瘤、免疫调节、疫苗佐剂、抗炎、抗凝、抗病毒、抗原生动物、抗菌、降血脂、再生医学治疗,以及药物输送和组织工程应用。本文旨在讨论海洋海藻中硫酸多糖的生物医学应用。