Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University.
Biol Pharm Bull. 2023;46(3):364-378. doi: 10.1248/bpb.b22-00887.
The interleukin 6 (IL-6) family of cytokines is defined by the usage of gp130, a common β-receptor signaling subunit, which promotes a variety of signals. They induce many biological functions on many cell types, including immune and inflammatory cells. They also exhibit hormone-like features, which are involved in homeostatic processes. Signal transducer and activator of transcription 3 (STAT3) is a significant signaling molecule fundamental in regulating IL-6/gp130 and is highly implicated in pathological conditions; therefore, STAT3 activation is tightly regulated through various mechanisms and at multiple levels. There is a large amount of information about STAT3-interacting proteins, which positively or negatively regulate STAT3 activity. This review is focused on IL-6-mediated signal transduction and the introduction of novel STAT3-binding partners. The review will help develop new strategies for clinically controlling the functions of IL-6/STAT3.
白细胞介素 6（IL-6）家族细胞因子的定义是使用 gp130，一种常见的β-受体信号亚基，它促进多种信号。它们诱导许多细胞类型的多种生物学功能，包括免疫和炎症细胞。它们还表现出激素样特征，参与体内平衡过程。信号转导和转录激活因子 3（STAT3）是一种重要的信号分子，对调节 IL-6/gp130 至关重要，并且在病理条件下高度涉及；因此，STAT3 激活通过各种机制和多个水平受到严格调节。关于 STAT3 相互作用蛋白有大量信息，这些蛋白正向或负向调节 STAT3 活性。这篇综述重点介绍了 IL-6 介导的信号转导以及新的 STAT3 结合伙伴的介绍。该综述将有助于制定临床控制 IL-6/STAT3 功能的新策略。
