Jelnes R, Bülow J, Tønnesen K H, Lassen N A, Holstein P
Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
Scand J Clin Lab Invest. 1987 Nov;47(7):649-54.
Simultaneous measurement during 24 h of mean arterial blood pressure (MABP) and forefoot subcutaneous adipose tissue blood flow (SBF) was undertaken in eight patients (15 feet) with different degrees of arterial insufficiency. The recordings were undertaken with the patients in the supine position only. The MABP decreased by 19 +/- 9% from awake to asleep independently of symptomatology. In two limbs with normal circulation, SBF decreased by 8 +/- 7%. In five limbs with arterial insufficiency but no rest pain SBF decreased by 16 +/- 8%, and in eight limbs with ischaemic nocturnal rest pain, SBF was reduced by 32 +/- 12% during sleep. It is concluded that nocturnal hypotension is the major aethiological factor for the symptom ischaemic nocturnal rest pain.
