Department of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11, Kosice, Slovakia.
Graduate School Kosice Institute for Society and Health, Faculty of Medicine, Pavol Jozef Safarik University, 040 11, Kosice, Slovakia.
Sci Rep. 2023 Mar 1;13(1):3491. doi: 10.1038/s41598-023-30621-z.
Previous research shows the beneficial effects of an intradialytic resistance training (IRT) on muscle function in haemodialysis patients. However, patients vary highly in their functional responses to IRT, may be due to effects of age and sex heterogeneities in adaptation. Therefore, the aim of this study was to investigate the degree to which the effects of IRT on the muscle function of haemodialysis patients vary by age and sex. We included 57 patients who completed a 12-week IRT (EXG) and 33 patients who received no IRT (CNG) during haemodialysis. Muscle function (MF) was assessed using dynamometry before and after a 12-week intervention and after a 12-week follow-up. After the 12-week intervention, we found a moderation effect of age in the relative (%) change (p = 0.011) and absolute (Δ) change (p = 0.027) of MF, and a moderation effect of sex in %MF (p = 0.001), but not in ΔMF (p = 0.069). Regarding patients' age, the change of MF was only significantly different between EXG and CNG patients aged 60-70 years (%MF, EXG: + 34.6%, CNG: - 20.1%, p < 0.001; ΔMF, EXG: + 44.4 N, CNG: - 22.1 N, p < 0.001). Regarding patients' sex, the change of MF was only significantly different between EXG and CNG female patients (%MF, EXG: + 23.9%, CNG: - 23.6%, p < 0.001). Age and sex did not significantly moderate changes in MF measures after 12 weeks of follow-up. We conclude that both age and sex of haemodialysis patients affect their functional response to IRT in the short term.Trial Registration: Intradialytic Resistance Training in Haemodialysis Patients (IRTHEP)-#NCT03511924, 30/04/2018, https://clinicaltrials.gov/ct2/show/NCT03511924 .
先前的研究表明，血液透析患者接受透析内抗阻训练（IRT）对肌肉功能有益。然而，患者对 IRT 的功能反应差异很大，这可能是由于年龄和性别对适应的影响。因此，本研究旨在探讨 IRT 对血液透析患者肌肉功能的影响在多大程度上因年龄和性别而异。我们纳入了 57 名接受为期 12 周 IRT（EXG）的患者和 33 名未接受 IRT（CNG）的患者。在透析期间，使用测力计在干预前、12 周干预后和 12 周随访后评估肌肉功能（MF）。12 周干预后，我们发现年龄对 MF 的相对（%）变化（p=0.011）和绝对（Δ）变化（p=0.027）具有调节作用，性别对 %MF（p=0.001）具有调节作用，但对ΔMF（p=0.069）没有调节作用。就患者年龄而言，只有年龄在 60-70 岁的 EXG 和 CNG 患者的 MF 变化在统计学上有显著差异（%MF，EXG：+34.6%，CNG：-20.1%，p<0.001；ΔMF，EXG：+44.4N，CNG：-22.1N，p<0.001）。就患者性别而言，只有 EXG 和 CNG 女性患者的 MF 变化在统计学上有显著差异（%MF，EXG：+23.9%，CNG：-23.6%，p<0.001）。12 周随访后，年龄和性别对 MF 测量的变化没有显著调节作用。我们的结论是，血液透析患者的年龄和性别都影响他们对短期 IRT 的功能反应。
血液透析患者透析内抗阻训练（IRTHEP）-#NCT03511924，30/04/2018，https://clinicaltrials.gov/ct2/show/NCT03511924。
