Department of Hematology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Hospitalist Division, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pediatr Blood Cancer. 2023 May;70(5):e30274. doi: 10.1002/pbc.30274. Epub 2023 Mar 1.
To evaluate attitudes toward vaccination and vaccine uptake regarding coronavirus disease 2019 (COVID-19) among pediatric patients with sickle cell disease (SCD) and their caregivers.
Adolescent patients and caregivers of children with SCD were surveyed during routine clinic visits; we then conducted a logistic regression analysis to understand differences in vaccine status, while qualitative responses were coded thematically.
Among respondents, the overall vaccination rate among adolescents and caregivers was 49% and 52%, respectively. Among the unvaccinated, 60% and 68% of adolescents and caregivers, respectively, preferred to remain unvaccinated, most commonly due to lack of perceived personal benefit from vaccination or mistrust in the vaccine. Multivariate logistic regression analysis showed that child's age (odds ratio [OR] = 1.1, 95% confidence interval [CI]: 1.0-1.2, p < .01) and caregiver education (measured by the Economic Hardship Index [EHI] score, OR = 0.76, 95% CI: 0.74-0.78, p < .05) were independent predictors of getting vaccinated.
Despite the increased risk of severe illness due to COVID-19 in patients with SCD, vaccine hesitancy remains high in this population of families whose children have SCD. Fortunately, the reasons cited for deferring vaccination among those who are unvaccinated were largely due to barriers that may be overcome with quality communication around the utility of the vaccine and information about vaccine safety.
评估镰状细胞病（SCD）患儿及其照顾者对 2019 年冠状病毒病（COVID-19）疫苗接种的态度和疫苗接种率。
在常规就诊期间对青少年患者和 SCD 患儿的照顾者进行调查；然后我们进行了逻辑回归分析，以了解疫苗接种状况的差异，同时对定性反应进行了主题编码。
在受访者中，青少年和照顾者的总体疫苗接种率分别为 49%和 52%。在未接种疫苗的人群中，分别有 60%和 68%的青少年和照顾者表示希望保持未接种状态，最常见的原因是他们认为接种疫苗对个人没有好处或不信任疫苗。多变量逻辑回归分析显示，儿童年龄（比值比[OR] = 1.1，95%置信区间[CI]：1.0-1.2，p <.01）和照顾者教育（由经济困难指数[EHI]评分衡量，OR = 0.76，95%CI：0.74-0.78，p <.05）是接种疫苗的独立预测因素。
尽管 COVID-19 使 SCD 患者患重病的风险增加，但在这个患有 SCD 的儿童的家庭中，疫苗犹豫仍然很高。幸运的是，那些未接种疫苗的人推迟接种疫苗的原因主要是由于对疫苗效用的沟通质量和有关疫苗安全性的信息存在障碍。
