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超声引导下双侧腹直肌鞘阻滞在犊牛脐疝修补术中的临床疗效:一项前瞻性随机试验

Clinical efficacy of an ultrasound-guided bilateral rectus sheath block for umbilical hernia repair in calves: A prospective randomized trial.

作者信息

Micieli Fabiana, Guccione Jacopo, Della Valle Giovanni, Alterisio Maria Chiara, Ciaramella Paolo, Vesce Giancarlo, Chiavaccini Ludovica

机构信息

Department of Veterinary Medicine and Animal Productions, University of Napoli Federico II, Napoli, Italy.

Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.

出版信息

Front Pain Res (Lausanne). 2023 Feb 13;4:1051504. doi: 10.3389/fpain.2023.1051504. eCollection 2023.

Abstract

INTRODUCTION

Surgical umbilical hernia repair is a frequent procedure in newborn calves, requiring mandatory pain management. This study aimed to develop an ultrasound-guided rectus sheath block (RSB) and to evaluate its clinical efficacy in calves undergoing umbilical herniorrhaphy under general field anesthesia.

METHODS

Gross and ultrasound anatomy of the ventral abdomen and the diffusion of a new methylene blue solution after injection within the rectus sheath were described in seven fresh calf cadavers. Then, fourteen calves undergoing elective herniorrhaphy were randomly assigned to receive either bilateral ultrasound-guided RSB with 0.3 mL/kg of bupivacaine 0.25% and 0.15 µg/kg of dexmedetomidine or 0.3 mL/kg of 0.9% NaCl (control). Intraoperative data included cardiopulmonary variables and anesthetic requirements. Postoperative data included pain scores, sedation scores and peri-incisional mechanical threshold assessed by force algometry at specific time points after anesthetic recovery. Treatments were compared using Wilcoxon rank-sum, Student's -test, and Cox proportional hazard model as appropriate. Mixed effect linear models on rank, with random effect calf; fixed effects time, treatment, and their interaction were used to compare pain scores and mechanical thresholds over time. Significance was set at = 0.05.

RESULTS AND DISCUSSION

Calves receiving RSB recorded lower pain scores between 45 - 120 minutes ( < 0.05) and at 240 min after recovery ( = 0.02). And they recorded higher mechanical thresholds between 45 and 120 min after surgery ( < 0.05). Ultrasound-guided RSB provided effective perioperative analgesia in calves undergoing herniorrhaphy under field conditions.

摘要

引言

外科脐疝修补术是新生犊牛常见的手术,需要进行强制性疼痛管理。本研究旨在开发一种超声引导下的腹直肌鞘阻滞(RSB),并评估其在全身局部麻醉下接受脐疝修补术的犊牛中的临床疗效。

方法

在七具新鲜犊牛尸体中描述了腹侧腹部的大体和超声解剖结构,以及注射新亚甲蓝溶液后在腹直肌鞘内的扩散情况。然后,将14只接受择期疝修补术的犊牛随机分为两组,一组接受双侧超声引导下的RSB,注射0.3 mL/kg的0.25%布比卡因和0.15 µg/kg的右美托咪定,另一组接受0.3 mL/kg的0.9%氯化钠(对照组)。术中数据包括心肺变量和麻醉需求。术后数据包括疼痛评分、镇静评分以及麻醉恢复后特定时间点通过压力痛觉计评估的切口周围机械阈值。根据情况使用Wilcoxon秩和检验、学生t检验和Cox比例风险模型比较治疗效果。使用具有随机效应犊牛的混合效应线性模型对秩进行分析;固定效应包括时间、治疗及其相互作用,用于比较不同时间的疼痛评分和机械阈值。显著性设定为α = 0.05。

结果与讨论

接受RSB的犊牛在恢复后45 - 120分钟(P < 0.05)和240分钟时(P = 0.02)疼痛评分较低。并且它们在术后45至120分钟时机械阈值较高(P < 0.05)。超声引导下的RSB为在野外条件下接受疝修补术的犊牛提供了有效的围手术期镇痛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d699/9969087/f9b4b7b716e6/fpain-04-1051504-g001.jpg

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