Toyoda Koji, Katayama Yasumi, Kobori Ikuhiro, Kitahama Akihiro, Kusano Yumi, Ono Yuko, Ban Shinichi, Tamano Masaya
Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City 343-8555, Japan.
Endoscopy Center, Dokkyo Medical University Saitama Medical Center, Koshigaya City 343-8555, Japan.
Oxf Med Case Reports. 2023 Feb 27;2023(2):omac157. doi: 10.1093/omcr/omac157. eCollection 2023 Feb.
Eosinophilic pancreatitis (EP) is very rare and characterised by infiltration of eosinophils into the pancreatic parenchyma. A 40-year-old man was diagnosed with total-colitis-type ulcerative colitis at the age of 15 years. He was then diagnosed with steroid-dependent ulcerative colitis. He was given golimumab, which resulted in remission. Ten months after beginning golimumab, he was urgently hospitalised with a diagnosis of acute pancreatitis. Hence, endoscopic ultrasound-guided fine needle biopsy was performed to obtain a definitive diagnosis. Pathologically, abundant infiltration of eosinophils was observed in the edematous intralobular stroma of the pancreas. He was diagnosed with EP, and treated with corticosteroids.
嗜酸性胰腺炎（EP）非常罕见，其特征是嗜酸性粒细胞浸润胰腺实质。一名40岁男性在15岁时被诊断为全结肠炎型溃疡性结肠炎。随后他被诊断为类固醇依赖型溃疡性结肠炎。他接受了戈利木单抗治疗，病情得到缓解。开始使用戈利木单抗10个月后，他因急性胰腺炎诊断而紧急住院。因此，进行了内镜超声引导下细针穿刺活检以明确诊断。病理检查显示，胰腺小叶内水肿间质中有大量嗜酸性粒细胞浸润。他被诊断为EP，并接受了皮质类固醇治疗。
