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一名溃疡性结肠炎患者发生嗜酸性胰腺炎的病例。

A case of eosinophilic pancreatitis in a patient with ulcerative colitis.

作者信息

Toyoda Koji, Katayama Yasumi, Kobori Ikuhiro, Kitahama Akihiro, Kusano Yumi, Ono Yuko, Ban Shinichi, Tamano Masaya

机构信息

Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City 343-8555, Japan.

Endoscopy Center, Dokkyo Medical University Saitama Medical Center, Koshigaya City 343-8555, Japan.

出版信息

Oxf Med Case Reports. 2023 Feb 27;2023(2):omac157. doi: 10.1093/omcr/omac157. eCollection 2023 Feb.

Abstract

Eosinophilic pancreatitis (EP) is very rare and characterised by infiltration of eosinophils into the pancreatic parenchyma. A 40-year-old man was diagnosed with total-colitis-type ulcerative colitis at the age of 15 years. He was then diagnosed with steroid-dependent ulcerative colitis. He was given golimumab, which resulted in remission. Ten months after beginning golimumab, he was urgently hospitalised with a diagnosis of acute pancreatitis. Hence, endoscopic ultrasound-guided fine needle biopsy was performed to obtain a definitive diagnosis. Pathologically, abundant infiltration of eosinophils was observed in the edematous intralobular stroma of the pancreas. He was diagnosed with EP, and treated with corticosteroids.

摘要

嗜酸性胰腺炎(EP)非常罕见,其特征是嗜酸性粒细胞浸润胰腺实质。一名40岁男性在15岁时被诊断为全结肠炎型溃疡性结肠炎。随后他被诊断为类固醇依赖型溃疡性结肠炎。他接受了戈利木单抗治疗,病情得到缓解。开始使用戈利木单抗10个月后,他因急性胰腺炎诊断而紧急住院。因此,进行了内镜超声引导下细针穿刺活检以明确诊断。病理检查显示,胰腺小叶内水肿间质中有大量嗜酸性粒细胞浸润。他被诊断为EP,并接受了皮质类固醇治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb0/9969831/ecd153de3a91/omac157f1.jpg

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