Reppucci Jennifer, Chang Michael, Hughes Steven, Liu Xiuli
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
Case Rep Gastroenterol. 2017 Mar 3;11(1):120-126. doi: 10.1159/000457788. eCollection 2017 Jan-Apr.
Eosinophilic pancreatitis is a rare form of recurrent acute pancreatitis that demonstrates distinct histologic features, including diffuse, periductal, acinar, and septal inflammatory infiltrates comprised of a pure or predominant population of eosinophils, eosinophilic phlebitis and arteritis, and localized eosinophilic infiltrates with pseudocyst formation. It is associated with elevated serum immunoglobulin E levels, an elevated eosinophil count with systemic manifestations, and eosinophilic infiltrates in other organs of the gastrointestinal tract. We present a case of eosinophilic pancreatitis in a 44-year-old man who was diagnosed after pancreatic resection for recurrent bouts of acute pancreatitis. While the gross and histologic evaluations matched other reported cases of eosinophilic pancreatitis, our patient had only minimal peripheral eosinophilia, no reported history of symptoms related to elevated eosinophilia or immunoglobulin E, and only mild eosinophilic infiltrates in his gallbladder.
嗜酸性胰腺炎是复发性急性胰腺炎的一种罕见形式，具有独特的组织学特征，包括由纯嗜酸性粒细胞或主要为嗜酸性粒细胞组成的弥漫性、导管周围、腺泡和间隔炎性浸润、嗜酸性静脉炎和动脉炎，以及伴有假囊肿形成的局限性嗜酸性浸润。它与血清免疫球蛋白E水平升高、伴有全身表现的嗜酸性粒细胞计数升高以及胃肠道其他器官的嗜酸性浸润有关。我们报告一例44岁男性嗜酸性胰腺炎病例，该患者因复发性急性胰腺炎接受胰腺切除术后确诊。虽然大体和组织学评估与其他报道的嗜酸性胰腺炎病例相符，但我们的患者仅有轻微的外周嗜酸性粒细胞增多，没有与嗜酸性粒细胞增多或免疫球蛋白E升高相关的症状史，且胆囊中仅有轻度嗜酸性浸润。
