Evans A C, Hollmann A W, du Preez L
Research Institute for Diseases in a Tropical Environment, South African Medical Research Council, Nelspruit, Tvl.
S Afr Med J. 1987 Nov 21;72(10):665-7.
Single 500 mg doses of mebendazole (Vermox; Janssen) were administered to 211 children aged 5 - 16 years in a rural area for treatment of single and mixed infestations with Ascaris lumbricoides, hookworm and Trichuris trichiura; the majority of subjects had low egg counts. Treatment was particularly effective against Ascaris, less effective against hookworm and promising against Trichuris. In most refractory cases egg output was considerably reduced. Treatment resulted in fewer Ascaris (95%) and hookworm (84%) ova reaching the environment. The results compare well with those obtained elsewhere in the world. One case of Strongyloides stercoralis infestation appeared after treatment. The drug was well tolerated and no side-effects were observed.
对农村地区211名5至16岁儿童单次服用500毫克甲苯咪唑（肠虫清；杨森公司生产），以治疗蛔虫、钩虫和鞭虫的单一感染及混合感染；大多数研究对象的虫卵计数较低。该治疗对蛔虫特别有效，对钩虫效果较差，对鞭虫有一定前景。在大多数难治性病例中，虫卵排出量大幅减少。治疗使到达环境中的蛔虫卵（95%）和钩虫卵（84%）减少。结果与世界其他地方获得的结果相当。治疗后出现1例粪类圆线虫感染病例。该药物耐受性良好，未观察到副作用。
