Abadi K
Am J Trop Med Hyg. 1985 Jan;34(1):129-33. doi: 10.4269/ajtmh.1985.34.129.
Four hundred and fifty subjects were included in a study of the prevalence of soil-transmitted nematodes in Ujung Pandang, South-Sulawesi, Indonesia. Trichuriasis was the most prevalent infection (93.3%), followed by ascariasis (80.2%) and hookworm infection (19.5%). Among 156 subjects who were given 500 mg of mebendazole in a single dose, treatment resulted in cure rates of 93.4%, 77.6%, and 91.1%, and average egg-count reduction rates of 99.0%, 92.8%, and 98.3%, for ascariasis, trichuriasis, and hookworm infections, respectively. Mebendazole appeared to be equally effective against necatoriasis and ancylostomiasis. The drug was well tolerated and almost no side effects were observed. Single dose mebendazole treatment appears to be relatively inexpensive, convenient, and effective in mass treatment for the control of intestinal nematode infections, especially in highly infected communities.
450名受试者参与了一项关于印度尼西亚南苏拉威西省乌戎潘当土壤传播线虫患病率的研究。鞭虫病是最普遍的感染（93.3%），其次是蛔虫病（80.2%）和钩虫感染（19.5%）。在156名单次服用500毫克甲苯达唑的受试者中，治疗对蛔虫病、鞭虫病和钩虫感染的治愈率分别为93.4%、77.6%和91.1%，平均虫卵计数减少率分别为99.0%、92.8%和98.3%。甲苯达唑对板口线虫病和钩虫病似乎同样有效。该药物耐受性良好，几乎未观察到副作用。单剂量甲苯达唑治疗在大规模治疗肠道线虫感染方面似乎相对便宜、方便且有效，尤其是在高感染社区。
