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罕见部位的广泛异位胰腺:病例报告及文献复习。

Extensive heterotopic pancreas in a rare site: A case report and a review of literature.

机构信息

Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

School of Medicine, Nankai University, Tianjin, China.

出版信息

Medicine (Baltimore). 2023 Mar 3;102(9):e32241. doi: 10.1097/MD.0000000000032241.

Abstract

RATIONALE

Heterotopic pancreas is a pancreatic tissue that occurs outside the normal anatomical site, the most common site is antrum. Due to the lack of specific imaging and endoscopic signs, heterotopic pancreas especially those occurring in the rare site, are often misdiagnosed, and leading to unnecessary surgical treatment. Endoscopic incisional biopsy and endoscopic ultrasound-guided fine-needle aspiration are effective means for diagnosing heterotopic pancreas. We reports a case of extensive heterotopic pancreas in a rare site, which was finally diagnosed by this way.

PATIENT CONCERNS

A 62-year-old man was admitted due to the presence of an angular notch lesion, which was suspected as gastric cancer before. He denied any history of tumor or gastric disease.

DIAGNOSES

No abnormality was found in the physical examination and laboratory testing after admission. Computed tomography showed localized thickening of the gastric wall measuring 30 mm in the long diameter. Gastroscope revealed a nodular-like submucosal protuberance at the angular notch with size of about 3*4 cm. Ultrasonic gastroscope showed that the lesion was located in the submucosa. The lesion exhibited mixed echogenicity. The diagnosis can not be identified.

INTERVENTIONS

2 times of incision biopsy were performed to make a clear diagnosis. Finally, appropriate tissue specimens were obtained for pathology testing.

OUTCOMES

The patient was diagnosed as heterotopic pancreas according to pathology. He was recommended to undergo observation and regular follow-ups rather than surgery. Then he was discharged home with no discomfort.

LESSONS

Heterotopic pancreas occurring in the angular notch is extremely rare, the site is scarcely reported in the relevant literature. Therefore, it is easy to be misdiagnosed. In the cases of an vague diagnosis, endoscopic incisional biopsy or endoscopic ultrasound-guided fine-needle aspiration may be a good choice.

摘要

背景

异位胰腺是一种发生在正常解剖部位以外的胰腺组织,最常见的部位是胃窦。由于缺乏特定的影像学和内镜下征象,异位胰腺,尤其是那些发生在罕见部位的胰腺,常被误诊,导致不必要的手术治疗。内镜下切开活检和内镜超声引导下细针抽吸是诊断异位胰腺的有效手段。我们报告了一例罕见部位广泛异位胰腺的病例,最终通过这种方法得到诊断。

病例介绍

一名 62 岁男性因存在角切迹病变而入院,该病变此前被怀疑为胃癌。他否认有任何肿瘤或胃部疾病史。

入院检查

体格检查和实验室检查均未见异常。计算机断层扫描显示胃壁局部增厚,长径 30mm。胃镜检查发现角切迹处有一结节样黏膜下隆起,大小约 3*4cm。超声胃镜显示病变位于黏膜下层。病变呈混合回声。无法明确诊断。

干预措施

进行了 2 次切开活检以明确诊断。最终,获得了适当的组织标本进行病理检查。

治疗结果

患者根据病理检查诊断为异位胰腺。建议他进行观察和定期随访,而不是手术。随后,他无不适症状出院。

结论

角切迹处发生的异位胰腺极为罕见,该部位在相关文献中鲜有报道。因此,容易误诊。在诊断不明确的情况下,内镜下切开活检或内镜超声引导下细针抽吸可能是一个不错的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b904/9981405/57b060439192/medi-102-e32241-g001.jpg

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