肺部肿瘤局部区域治疗的血管内治疗技术
Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors.
作者信息
Vogl Thomas J, Mekkawy Ahmed, Thabet Duaa B
机构信息
Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany.
Department of Chest Diseases, Assiut University, Assiut, Egypt.
出版信息
Rofo. 2023 Jul;195(7):579-585. doi: 10.1055/a-2001-5289. Epub 2023 Mar 2.
BACKGROUND
Lung cancer incidence has greatly increased over the past century. Moreover, the lung is the most common site of metastatic involvement. Despite improvements in the diagnosis and treatment of lung malignancies, patient prognosis is still unsatisfactory. Locoregional chemotherapeutic techniques for the treatment of lung malignancies are the current focus of research. The aim of this review article is to present different locoregional intravascular techniques and their treatment principles and to assess the pros and cons of each of them as a palliative and neoadjuvant treatment method in the treatment of lung malignancy.
METHOD
The different methods for the treatment of malignant lung lesions such as isolated lung perfusion (ILP), selective pulmonary artery perfusion (SPAP), transpulmonary chemoembolization (TPCE), bronchial artery infusion (BAI), bronchioarterial chemoembolization (BACE), and intraarteriel chemoperfusion (IACP) are evaluated comparatively.
RESULTS
Locoregional intravascular chemotherapy procedures are proving to be promising treatment options in the management of malignant lung tumors. In order to achieve optimal results, the locoregional technique should be used to achieve the highest possible uptake of the chemotherapeutic agent into the target tissue with rapid systemic clearance.
CONCLUSION
Among the various treatment options for lung malignancies, TPCE is the best evaluated treatment concept. However, further studies are necessary to define the optimal treatment concept with the best clinical outcomes.
KEY POINTS
· There are various intravascular chemotherapy methods for the treatment of lung malignancies.. · Transpulmonary chemoembolization (TPCE) is currently the most extensively evaluated treatment method for lung malignancies.. · Thermoablation after neoadjuvant chemoperfusion is a promising therapy for treating lung malignancies..
CITATION FORMAT
· Vogl TJ, Mekkawy A, Thabet DB. Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors. Fortschr Röntgenstr 2023; 195: 579 - 585.
背景
在过去的一个世纪里，肺癌的发病率大幅上升。此外，肺是转移累及最常见的部位。尽管肺癌的诊断和治疗有所改善，但患者的预后仍然不尽人意。局部区域化疗技术治疗肺癌是目前的研究重点。这篇综述文章的目的是介绍不同的局部区域血管内技术及其治疗原则，并评估它们作为肺癌姑息性和新辅助治疗方法的优缺点。
方法
对治疗恶性肺病变的不同方法进行比较评估，如孤立肺灌注（ILP）、选择性肺动脉灌注（SPAP）、经肺化疗栓塞（TPCE）、支气管动脉灌注（BAI）、支气管动脉化疗栓塞（BACE）和动脉内化学灌注（IACP）。
结果
局部区域血管内化疗程序在恶性肺肿瘤的治疗中被证明是有前景的治疗选择。为了取得最佳效果，应采用局部区域技术，使化疗药物在目标组织中的摄取量尽可能高，同时实现快速的全身清除。
结论
在肺癌的各种治疗选择中，TPCE是评估最好的治疗理念。然而，需要进一步研究来确定具有最佳临床结果的最佳治疗理念。
要点
· 有多种血管内化疗方法用于治疗肺癌。· 经肺化疗栓塞（TPCE）是目前对肺癌评估最广泛的治疗方法。· 新辅助化学灌注后热消融是治疗肺癌的一种有前景的疗法。
引用格式
· Vogl TJ, Mekkawy A, Thabet DB. Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors. Fortschr Röntgenstr 2023; 195: 579 - 585.
Zotero 插件