Diadyk A I, Dikshteĭn E A, Vasilenko I V, Siniachenko O V, Kobets V G
Ter Arkh. 1987;59(8):35-7.
The paper is concerned with clinico-laboratory correlations and assessment of short- and long-term results of glucocorticoid therapy (GCT) in 137 patients with diffuse mesangioproliferative glomerulonephritis (DMPGN). It may have different clinical variants and is characterized by a relatively favorable course in the first 10 yrs. A good clinical effect of GCT was observed only in some patients with the nephrotic variant of DMPGN in the absence or presence of insignificant fibroplastic changes, and in the absence or presence of the moderate tubulointerstitial component. In patients with a latent variant of DMPGN GCT made no considerable effect on the clinical symptoms of disease. The 15-year survival in patients on GCT was slightly higher (insignificant statistical difference) than that in patients receiving symptomatic treatment only.
本文关注137例弥漫性系膜增生性肾小球肾炎（DMPGN）患者糖皮质激素治疗（GCT）的临床实验室相关性及短期和长期结果评估。它可能有不同的临床变体，在前10年病程相对良好。仅在一些DMPGN肾病变体患者中观察到GCT有良好临床效果，这些患者不存在或仅有轻微纤维增生性改变，且不存在或仅有中度肾小管间质成分。在DMPGN潜伏变体患者中，GCT对疾病临床症状无显著影响。接受GCT治疗患者的15年生存率略高于仅接受对症治疗的患者（统计学差异不显著）。
