Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Sandra and Edward Meyer Cancer Center, New York, NY, USA.
J Transl Med. 2023 Mar 2;21(1):162. doi: 10.1186/s12967-023-04017-6.
Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.
哺乳动物细胞对稳态的特定扰动做出反应，可以经历一种受调控的细胞死亡变体，从而引发适应性免疫反应。由于免疫原性细胞死亡（ICD）只能在特定的细胞和机体环境中发生，因此应该与那些在机制上不依赖于细胞死亡的免疫刺激或炎症反应区分开来。在这里，我们批判性地讨论了 ICD 的关键概念和机制方面及其对癌症（免疫）治疗的影响。
