Khaliq O P, Phoswa W N, Moodley J
Department of Obstetrics and Gynaecology and Women's Health and HIV Research Group, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Department of Life and Consumer Sciences, University of South Africa, Science Campus, Roodepoort, South Africa.
Front Reprod Health. 2023 Feb 13;5:1120937. doi: 10.3389/frph.2023.1120937. eCollection 2023.
Congo Red Dot Paper Test (CRDPT) appears to be a simple, cost-effective, non-invasive diagnostic tool for hypertensive disorders of pregnancy (HDP). The main objective of the study is to assess the effectiveness of CRDPT in detecting HDP.
This is a systemic review and meta-analysis of published studies on the effectiveness of CRDPT in the detection of HDP. The study was conducted in line with the PRISMA-DTA guidelines. The PICOS framework was used to search for relevant articles using Medline, PubMed, Google Scholar, Web of Science, and the Cochrane Library databases. The articles were screened against a set of inclusion and exclusion criteria and analysed using the Review Manager 5.4 software.
A title, abstract and full article screening was conducted on 18,153 potential articles based on the inclusion and exclusion criteria. The screening yielded five articles for meta-analysis. The total number of normotensive pregnant women ( = 3,380) in the included studies was five times higher than the total number of women with pre-eclampsia ( = 535). A difference between the HDP and normotensive group was noted. This is indicated by a significantly decreased in the effectiveness of CRDPT in detecting HDP as compared to normotensive group [Risk Ratio (RR) = 6.32 (2.17, 18.43) < 0.00001]. The included studies had a high nature of heterogeneity ( = 98%, < 0.00001) partially due to different study designs included in the analysis and different regions where studies were conducted given that none of these studies were conducted in African countries where HDP is prominent.
According to results generated from 5 studies in this meta-analysis, it was found that CRDPT might not be effective in the detection of hypertensive disorder of pregnancy. Moreover, more research, especially in African women where hypertensive disorders of pregnancy are prevalent, are re-quired to ascertain these findings.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021283679, identifier: CRD42021283679.
刚果红点纸试验（CRDPT）似乎是一种用于诊断妊娠期高血压疾病（HDP）的简单、经济高效且无创的诊断工具。本研究的主要目的是评估CRDPT在检测HDP方面的有效性。
这是一项对已发表的关于CRDPT检测HDP有效性的研究进行的系统评价和荟萃分析。该研究按照PRISMA-DTA指南进行。使用PICOS框架在Medline、PubMed、谷歌学术、科学网和Cochrane图书馆数据库中检索相关文章。根据一组纳入和排除标准对文章进行筛选，并使用Review Manager 5.4软件进行分析。
根据纳入和排除标准，对18153篇潜在文章进行了标题、摘要和全文筛选。筛选出5篇文章进行荟萃分析。纳入研究中血压正常的孕妇总数（n = 3380）比先兆子痫孕妇总数（n = 535）高出五倍。注意到HDP组和血压正常组之间存在差异。这表现为与血压正常组相比，CRDPT检测HDP的有效性显著降低[风险比（RR）= 6.32（2.17，18.43），P < 0.00001]。纳入的研究具有高度异质性（I² = 98%，P < 0.00001），部分原因是分析中纳入的研究设计不同以及研究开展的地区不同，因为这些研究均未在HDP高发的非洲国家进行。
根据该荟萃分析中5项研究得出的结果，发现CRDPT在检测妊娠期高血压疾病方面可能无效。此外，需要更多研究，尤其是在妊娠期高血压疾病普遍的非洲女性中进行研究，以确定这些发现。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021283679，标识符：CRD
