Khosravi Kimia, Monajemi Mamaghani Arman, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
These authors contributed eqully to this work.
Iran J Basic Med Sci. 2023 Mar;26(3):255-268. doi: 10.22038/IJBMS.2022.64967.14304.
Rech. F. & Wendelbo. traditionally has been used in several remedies, as a carminative agent especially for children, as an antiseptic agent, and it is used in treating diarrhea, stomach irritations, headaches, colds, convulsions, spasms, dysmenorrhea, and healing wounds. According to clinical studies, it is highly effective for reducing inflammation and pain, treating bacterial and fungal infections, morphine tolerance, morphine dependence, withdrawal syndrome symptoms, convulsions, and diabetes. The goal of this review is to find therapeutic opportunities by analyzing the traditional uses and pharmacological effects of the chemical constituents of The information on in this review was gathered from scientific databases or search engines (PubMed, Wiley Online Library, Scopus, SID, Google Scholar, and Microsoft Academic). The literature cited in this review dates from 1992 to 2021. Several bioactive components including linalool, camphor, manool, and bioactive diterpenoids are presen in different parts of . Various properties were observed such as antioxidant, antinociceptive, anti-inflammatory, antimicrobial, antiviral, larvicidal, anticonvulsant, antidiabetic, and anticancer properties. Also, the effect of on morphine tolerance, morphine dependence, and withdrawal syndrome as well as its toxicology has been established. Although there are and animal studies on several pharmacological effects of , the lack of clinical studies is significant. Therefore, further clinical trials should be performed to confirm the and animal findings.
雷奇.F.和温德尔博。传统上已被用于多种药物中，作为一种特别是对儿童的驱风剂、防腐剂，还用于治疗腹泻、胃部不适、头痛、感冒、惊厥、痉挛、痛经和伤口愈合。根据临床研究，它在减轻炎症和疼痛、治疗细菌和真菌感染、吗啡耐受性、吗啡依赖性、戒断综合征症状、惊厥和糖尿病方面非常有效。本综述的目的是通过分析其化学成分的传统用途和药理作用来寻找治疗机会。本综述中关于它的信息是从科学数据库或搜索引擎（PubMed、Wiley Online Library、Scopus、SID、谷歌学术和微软学术）收集的。本综述中引用的文献日期为1992年至2021年。它的不同部位存在几种生物活性成分，包括芳樟醇、樟脑、异海松醇和生物活性二萜类化合物。观察到了各种特性，如抗氧化、抗伤害感受、抗炎、抗菌、抗病毒、杀幼虫、抗惊厥、抗糖尿病和抗癌特性。此外，它对吗啡耐受性、吗啡依赖性和戒断综合征的影响及其毒理学也已得到证实。尽管有关于它几种药理作用的体外和动物研究，但临床研究的缺乏很明显。因此，应进行进一步的临床试验以证实体外和动物研究结果。
