土木香挥发油对小鼠吗啡耐受及依赖的影响。
Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice.
机构信息
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Chin J Integr Med. 2020 Sep;26(9):683-687. doi: 10.1007/s11655-020-3424-9. Epub 2020 Jul 27.
OBJECTIVE
To evaluate the effects of Zhumeria majdae essential oil (ZMEO) on morphine dependence and tolerance in mice.
METHODS
ZMEO (10, 20, and 40 mg/kg) and clonidine (0.1 mg/kg) as the positive control were injected intraperitoneally (i.p.). The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone (5 mg/kg) while the tolerance was evaluated by the tail-flick test.
RESULTS
ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance (P<0.01), while it led to reduced morphine dependence with the doses of 20 and 40 mg/kg. ZMEO at two dose levels of 20 and 40 mg/kg indicated significant antinociceptive activity (P>0.01), and significantly reduced the withdrawal signs (number of jumps) of mice (P>0.01).
CONCLUSIONS
ZMEO had significant effects on morphine tolerance and dependence. The linalool rich essential oil of Z. majdae plays a major role in the reduction of tolerance and dependence induced by morphine.
目的
评价土木香挥发油（ZMEO）对小鼠吗啡依赖和耐受的影响。
方法
ZMEO（10、20 和 40mg/kg）和可乐定（0.1mg/kg）作为阳性对照，腹腔注射。通过计算纳洛酮（5mg/kg）诱导的跳跃次数来评估 ZMEO 和可乐定对依赖的影响，通过尾巴闪烁试验来评估耐受。
结果
在形成期，10mg/kg 的 ZMEO 显著抑制吗啡耐受（P<0.01），而 20 和 40mg/kg 的 ZMEO 导致吗啡依赖减少。20 和 40mg/kg 两个剂量水平的 ZMEO 均表现出明显的镇痛活性（P>0.01），并显著减少了小鼠的戒断症状（跳跃次数）（P>0.01）。
结论
ZMEO 对吗啡耐受和依赖有显著影响。土木香富含的 linalool 精油在降低吗啡诱导的耐受和依赖方面起主要作用。
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