Sharma R P, Flora S J, Drown D B, Oberg S G
Center for Environmental Toxicology, Utah State University, Logan 84322-5600.
Toxicol Ind Health. 1987 Sep;3(3):321-9. doi: 10.1177/074823378700300304.
Translocation and tissue distribution of two different forms of vanadium compounds, orthovanadate (soluble) and vanadium pentoxide (less soluble), were investigated. Groups of randomly selected rats were injected intratracheally with radiolabeled vanadium (48V) compounds and the animals were sacrificed at 1, 7 and 28 days after treatment. Blood, lungs and other major organs and tissues, namely liver, kidney, spleen, heart, testes, brain, muscle, and bone were sampled and the vanadium contents determined by gamma spectrometry. The less soluble form of vanadium (vanadium pentoxide) was eliminated from the lungs at a slow but exponentially linear rate, whereas the soluble form was translocated rapidly from this organ and exhibited a non-linear decline. Compared to the less soluble form, significantly less vanadium was retained in lungs 7 and 28 days after intratracheal instillation of vanadate. One day after treatment significantly higher concentrations (approximately 4 times) of vanadium after orthovanadate were observed in liver, kidney, spleen and bone compared to the pentoxide. However, tissue residues at 7 and 28 days indicated that both forms of vanadium were rapidly eliminated, except from bone and lungs. Results suggest a prolonged retention of less soluble forms of vanadium and possible health effects following repeated occupational exposure.
研究了两种不同形式的钒化合物，即原钒酸盐（可溶）和五氧化二钒（难溶）的转运及组织分布情况。随机选取几组大鼠，经气管内注射放射性标记的钒（⁴⁸V）化合物，并在处理后1天、7天和28天处死动物。采集血液、肺以及其他主要器官和组织，即肝脏、肾脏、脾脏、心脏、睾丸、大脑、肌肉和骨骼，并通过γ能谱法测定钒含量。难溶形式的钒（五氧化二钒）以缓慢但呈指数线性的速率从肺中清除，而可溶形式的钒则迅速从该器官转运出去，并呈现非线性下降。与难溶形式相比，经气管内滴注钒酸盐后7天和28天，肺中保留的钒明显较少。处理后1天，与五氧化二钒相比，原钒酸盐处理后肝脏、肾脏、脾脏和骨骼中的钒浓度显著更高（约4倍）。然而，7天和28天的组织残留表明，除了骨骼和肺外，两种形式的钒都被迅速清除。结果表明，难溶形式的钒会长期留存，反复职业接触可能会对健康产生影响。
