Aihara M, Sharma R P, Shupe J L
Toxicology. 1985 Aug;36(2-3):109-18. doi: 10.1016/0300-483x(85)90045-9.
An autoradiographic study was undertaken to compare the initial distribution patterns of soluble and less soluble forms of cadmium in the rat lung after intratracheal (i.t.) instillation. Male Sprague--Dawley rats were divided into 2 groups, each group received either soluble or a less soluble cadmium (109Cd) i.t. in 0.1 ml buffered saline. At 5, 30 and 90 min post-instillation, rats were sacrificed and processed for autoradiography, and radioactivity estimation of lung sections. 109Cd was unevenly distributed in the lungs at 5 min for both forms of Cd. At 90 min post-instillation, 109Cd was almost evenly distributed in the lung instilled with the soluble form; in case of the less soluble form a spotty distribution of 109Cd in the bronchi was observed. 109Cd was mainly translocated to the liver and stomach, followed by the kidney and intestine. It is apparent that the initial translocation of instilled 109Cd from the lung is relatively slow in the case of less soluble form as compared with the soluble form.
进行了一项放射自显影研究，以比较气管内（i.t.）滴注后大鼠肺中镉的可溶形式和难溶形式的初始分布模式。雄性Sprague-Dawley大鼠分为2组，每组在0.1 ml缓冲盐水中接受可溶或难溶镉（109Cd）的气管内滴注。在滴注后5、30和90分钟，处死大鼠并进行放射自显影处理以及肺切片的放射性估计。两种形式的镉在5分钟时在肺中的分布均不均匀。滴注后90分钟，109Cd在注入可溶形式的肺中几乎均匀分布；对于难溶形式，观察到109Cd在支气管中呈斑点状分布。109Cd主要转移到肝脏和胃，其次是肾脏和肠道。显然，与可溶形式相比，难溶形式的注入109Cd从肺中的初始转移相对较慢。
