[钒在未孕和怀孕Wistar大鼠组织中的分布]

[Distribution of vanadium in tissues of nonpregnant and pregnant Wistar rats].

作者信息

Li S, Zhang T, Yang Z, Gou X

机构信息

Department of Environmental Health.

出版信息

Hua Xi Yi Ke Da Xue Xue Bao. 1991 Jun;22(2):196-200.

PMID:1786960

Abstract

This paper reports tissue distribution of vanadium in nonpregnant and pregnant Wistar rats. The experimental results showed that vanadium concentrations in nonpregnant rats were respectively from high to low: I. no treatment: ovary greater than uterus greater than kidney greater than lung greater than heart muscle greater than spleen greater than brain greater than liver greater than blood; II. 4h after single i.p. injection of V2O5 (5 mg/kg): kidney greater than ovary greater than liver greater than bone greater than uterus greater than lung greater than heart muscle greater than spleen greater than brain greater than blood. The results suggest that female genital organs are important organs in distribution of vanadium. The kidney is a main excretory organ. After 24h of treatment, a larger amount of vanadium in body has been excreted. Vanadium can pass through blood-brain barrier. Distribution of vanadium on gestation days 12 after 4h single i.p. injection of V2O5 (5 mg/kg) is: kidney greater than ovary greater than uterus greater than placenta greater than liver greater than fetus greater than bone greater than heart muscle greater than lung greater than brain greater than spleen greater than blood; on gestation days 16-18 after 4h single i.p. injection of V2O5 (5 mg/kg) is: kidney ovary greater than placenta greater than lung greater than bone greater than uterus greater than heart muscle greater than spleen greater than fetus greater than liver greater than brain greater than blood; after 24h (on gestation days 16-18) is: kidney greater than ovary greater than placenta greater than spleen greater than bone greater than lung greater than liver greater than fetus heart muscle greater than brain blood.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本文报道了钒在未孕和孕Wistar大鼠体内的组织分布情况。实验结果表明，未孕大鼠体内钒浓度从高到低依次为：I. 未处理组：卵巢＞子宫＞肾脏＞肺＞心肌＞脾脏＞脑＞肝脏＞血液；II. 单次腹腔注射V2O5（5毫克/千克）4小时后：肾脏＞卵巢＞肝脏＞骨骼＞子宫＞肺＞心肌＞脾脏＞脑＞血液。结果表明，雌性生殖器官是钒分布的重要器官。肾脏是主要的排泄器官。处理24小时后，体内大量的钒已被排出。钒可通过血脑屏障。单次腹腔注射V2O5（5毫克/千克）4小时后，妊娠第12天钒的分布为：肾脏＞卵巢＞子宫＞胎盘＞肝脏＞胎儿＞骨骼＞心肌＞肺＞脑＞脾脏＞血液；单次腹腔注射V2O5（5毫克/千克）4小时后，妊娠第16 - 18天钒的分布为：肾脏＞卵巢＞胎盘＞肺＞骨骼＞子宫＞心肌＞脾脏＞胎儿＞肝脏＞脑＞血液；24小时后（妊娠第16 - 18天）为：肾脏＞卵巢＞胎盘＞脾脏＞骨骼＞肺＞肝脏＞胎儿＞心肌＞脑＞血液。（摘要截选于250字）