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脓毒症和脓毒性休克重症患者的代谢复苏治疗：一项前瞻性随机对照试验的初步研究

Metabolic resuscitation therapy in critically ill patients with sepsis and septic shock: A pilot prospective randomized controlled trial.

作者信息

Feng Fang, Yang Huyong, Yang Weiwei, Chen Yu

机构信息

Intensive Care Unit of Lanzhou University Second Hospital, No. 82, Cuiying Gate, Chengguanqu, Lanzhou, Gansu 730000, China.

Intensive Care Unit of People's Hospital of Linxia State, Linxia, Gansu 730000, China.

出版信息

Open Med (Wars). 2023 Feb 25;18(1):20230637. doi: 10.1515/med-2023-0637. eCollection 2023.

DOI:10.1515/med-2023-0637
PMID:36865494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9971735/
Abstract

The main purpose of our research was to further clarify the effectiveness and potential pathophysiological principles of metabolic resuscitation therapy in critically ill patients with sepsis and septic shock. We found that metabolic resuscitation therapy is beneficial for patients with sepsis and septic shock, shortening the length of intensive care unit (ICU) stay, reducing the duration of vasopressor use, and reducing the ICU mortality rate of patients with sepsis and septic shock, but it does not reduce the hospital mortality rate.

摘要

我们研究的主要目的是进一步阐明代谢复苏治疗对脓毒症和脓毒性休克重症患者的有效性及潜在病理生理机制。我们发现，代谢复苏治疗对脓毒症和脓毒性休克患者有益，可缩短重症监护病房（ICU）住院时间，减少血管活性药物使用时长，并降低脓毒症和脓毒性休克患者的ICU死亡率，但并未降低医院死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/ef0bfc6007c1/j_med-2023-0637-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/fa1473508ba4/j_med-2023-0637-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/9a8c9fd0edbd/j_med-2023-0637-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/bee32c8a182e/j_med-2023-0637-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/ef0bfc6007c1/j_med-2023-0637-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/fa1473508ba4/j_med-2023-0637-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/9a8c9fd0edbd/j_med-2023-0637-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/bee32c8a182e/j_med-2023-0637-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/9971735/ef0bfc6007c1/j_med-2023-0637-fig004.jpg

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Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock.硫胺素治疗对感染性休克患者乳酸清除率和死亡率的影响。
Crit Care Med. 2018 Nov;46(11):1747-1752. doi: 10.1097/CCM.0000000000003311.
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Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis.脓毒症中的皮质类固醇：更新的系统评价和荟萃分析。
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Intensive Care Med. 2018 Jul;44(7):1003-1016. doi: 10.1007/s00134-018-5197-6. Epub 2018 May 14.
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