Saeed Saboor, Cao Jianqing, Xu Jinjiao, Zhang Yi, Zheng Xuyang, Jiang Liya, Jiang Chunming, Zhang Xinjuan
Department of Pediatrics, International Education College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Department of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Front Pediatr. 2023 Feb 14;11:1068301. doi: 10.3389/fped.2023.1068301. eCollection 2023.
Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2, is a rare but serious complication of SARS-CoV-2 infection in children that typically occurs 2-6 weeks after SARS-CoV-2 infection. The pathophysiology of MIS-C is unknown. MIS-C, first recognized in April 2020, is characterized by fever, systemic inflammation, and multi-system organ involvement. Post-vaccination adverse effects have increased with COVID-19 vaccinations, and MIS linked to immunization with COVID-19 vaccines has also been observed.
An 11-year-old Chinese girl presented with a high-grade fever, rash, and dry cough for 2 days. She had her 2nd SARS-CoV-2 inactivated vaccination dose five days before hospital admission. On day 3 & 4, she experienced bilateral conjunctivitis, hypotension (66/47 mmHg), and a high CRP level. She was diagnosed with MIS-C. The patient's condition deteriorated rapidly, necessitating intensive care unit admission. The patient's symptoms improved after intravenous immunoglobulin, methylprednisolone, and oral aspirin therapy. She was discharged from the hospital after 16 days as her general condition, and laboratory biomarkers returned to normal.
Inactivated Covid-19 vaccination might trigger MIS-C. Further research is needed to evaluate whether a correlation exists between COVID-19 vaccination and MIS-C development.
儿童多系统炎症综合征（MIS-C），也称为小儿炎症性多系统综合征，与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在时间上相关，是儿童SARS-CoV-2感染的一种罕见但严重的并发症，通常发生在SARS-CoV-2感染后2至6周。MIS-C的病理生理学尚不清楚。MIS-C于2020年4月首次被认识，其特征为发热、全身炎症和多系统器官受累。随着2019冠状病毒病（COVID-19）疫苗接种的增加，接种疫苗后的不良反应也有所增加，并且也观察到了与COVID-19疫苗接种相关的MIS。
一名11岁中国女孩出现高热、皮疹和干咳2天。她在入院前5天接种了第2剂SARS-CoV-2灭活疫苗。在第3天和第4天，她出现双侧结膜炎、低血压（66/47 mmHg）和高C反应蛋白水平。她被诊断为MIS-C。患者病情迅速恶化，需要入住重症监护病房。经静脉注射免疫球蛋白、甲泼尼龙和口服阿司匹林治疗后，患者症状改善。16天后，由于她的一般状况和实验室生物标志物恢复正常，她出院了。
SARS-CoV-2灭活疫苗接种可能引发MIS-C。需要进一步研究以评估COVID-19疫苗接种与MIS-C发生之间是否存在相关性。
