血清可溶性细胞间黏附分子-1（sICAM-1）：重度寻常痤疮中一种新型潜在生物标志物。
Serum Soluble Intercellular Adhesion Molecule-1 (sICAM-1): A Novel Potential Biomarker in Severe Acne Vulgaris.
作者信息
Mustafa Amany Ibrahim, Ebrahim Adel Ali, Abel Halim Waleed Abdel Lateef, Fawzy Eman, Abdou Ahmed Fathy
机构信息
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt.
出版信息
Indian J Dermatol. 2022 Sep-Oct;67(5):512-517. doi: 10.4103/ijd.ijd_387_21.
BACKGROUND
Acne vulgaris (AV) is a chronic inflammatory disorder. Intercellular adhesion molecule-1 (ICAM-1) is a vital adhesion molecule mediating cellular adhesion during the inflammatory process.
AIMS AND OBJECTIVES
To evaluate serum soluble intercellular adhesion molecule-1 (sICAM-1) level in AV patients as an attempt to elucidate its role in acne pathogenesis and to relate with studied clinical parameters.
MATERIALS AND METHODS
Serum sICAM-1 level was measured using ELISA technique in 60 patients and 60 controls.
RESULTS
Serum sICAM-1 level was significantly elevated in studied patients than controls ( < 0.001). Additionally, its level increased significantly with increased acne severity ( < 0.001) but not in patients with post acne scars ( > 0.05).
CONCLUSION
Serum sICAM-1 could be a marker for acne etiopathogenesis. Furthermore, it might be considered as a predictor for disease severity.
背景
寻常痤疮（AV）是一种慢性炎症性疾病。细胞间黏附分子-1（ICAM-1）是一种在炎症过程中介导细胞黏附的重要黏附分子。
目的
评估寻常痤疮患者血清可溶性细胞间黏附分子-1（sICAM-1）水平，以阐明其在痤疮发病机制中的作用，并与所研究的临床参数相关联。
材料与方法
采用酶联免疫吸附测定（ELISA）技术检测60例患者和60例对照者的血清sICAM-1水平。
结果
研究患者的血清sICAM-1水平显著高于对照组（<0.001）。此外，其水平随痤疮严重程度的增加而显著升高（<0.001），但痤疮后瘢痕患者的水平无显著变化（>0.05）。
结论
血清sICAM-1可能是痤疮病因发病机制的一个标志物。此外，它可能被视为疾病严重程度的一个预测指标。
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