大气一氧化碳暴露与呼吸道疾病住院风险的关联：中国赣州的一项时间序列研究。

Association of ambient carbon monoxide exposure with hospitalization risk for respiratory diseases: A time series study in Ganzhou, China.

机构信息

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Front Public Health. 2023 Feb 14;11:1106336. doi: 10.3389/fpubh.2023.1106336. eCollection 2023.

DOI:10.3389/fpubh.2023.1106336

PMID:36866098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9972102/

Abstract

BACKGROUND

Ambient carbon monoxide (CO) exposure is associated with increased mortality and hospitalization risk for total respiratory diseases. However, evidence on the risk of hospitalization for specific respiratory diseases from ambient CO exposure is limited.

METHODS

Data on daily hospitalizations for respiratory diseases, air pollutants, and meteorological factors from January 2016 to December 2020 were collected in Ganzhou, China. A generalized additive model with the quasi-Poisson link and lag structures was used to estimate the associations between ambient CO concentration and hospitalizations of total respiratory diseases, asthma, chronic obstructive pulmonary disease (COPD), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), and influenza-pneumonia. Possible confounding co-pollutants and effect modification by gender, age, and season were considered.

RESULTS

A total of 72,430 hospitalized cases of respiratory diseases were recorded. Significant positive exposure-response relationships were observed between ambient CO exposure and hospitalization risk from respiratory diseases. For each 1 mg/m increase in CO concentration (lag0-2), hospitalizations for total respiratory diseases, asthma, COPD, LRTI, and influenza-pneumonia increased by 13.56 (95% CI: 6.76%, 20.79%), 17.74 (95% CI: 1.34%, 36.8%), 12.45 (95% CI: 2.91%, 22.87%), 41.25 (95% CI: 18.19%, 68.81%), and 13.5% (95% CI: 3.41%, 24.56%), respectively. In addition, the associations of ambient CO with hospitalizations for total respiratory diseases and influenza-pneumonia were stronger during the warm season, while women were more susceptible to ambient CO exposure-associated hospitalizations for asthma and LRTI (all < 0.05).

CONCLUSION

In brief, significant positive exposure-response relationships were found between ambient CO exposure and hospitalization risk for total respiratory diseases, asthma, COPD, LRTI, and influenza-pneumonia. Effect modification by season and gender was found in ambient CO exposure-associated respiratory hospitalizations.

摘要

背景

环境一氧化碳（CO）暴露与总呼吸系统疾病的死亡率和住院风险增加有关。然而，环境 CO 暴露导致特定呼吸系统疾病住院的风险证据有限。

方法

收集了 2016 年 1 月至 2020 年 12 月中国赣州的每日呼吸系统疾病住院数据、空气污染物和气象因素数据。采用广义加性模型与拟泊松链接和滞后结构，估计环境 CO 浓度与总呼吸系统疾病、哮喘、慢性阻塞性肺疾病（COPD）、上呼吸道感染（URTI）、下呼吸道感染（LRTI）和流感肺炎住院之间的关联。考虑了可能的混杂污染物和性别、年龄和季节的效应修饰。

结果

共记录了 72430 例呼吸系统疾病住院病例。环境 CO 暴露与呼吸系统疾病住院风险之间存在显著的正暴露反应关系。CO 浓度每增加 1mg/m（lag0-2），总呼吸系统疾病、哮喘、COPD、LRTI 和流感肺炎的住院人数分别增加 13.56（95%置信区间：6.76%，20.79%）、17.74（95%置信区间：1.34%，36.8%）、12.45（95%置信区间：2.91%，22.87%）、41.25（95%置信区间：18.19%，68.81%）和 13.5%（95%置信区间：3.41%，24.56%）。此外，在温暖季节，环境 CO 与总呼吸系统疾病和流感肺炎住院的关联更强，而女性对环境 CO 暴露相关的哮喘和 LRTI 住院更为敏感（均<0.05）。