Ung Choong Yong, Correia Cristina, Billadeau Daniel Denis, Zhu Shizhen, Li Hu
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
Department of Immunology, Mayo Clinic, Rochester, MN, United States.
Front Cell Dev Biol. 2023 Feb 14;11:1122422. doi: 10.3389/fcell.2023.1122422. eCollection 2023.
Despite the promising advances in regenerative medicine, there is a critical need for improved therapies. For example, delaying aging and improving healthspan is an imminent societal challenge. Our ability to identify biological cues as well as communications between cells and organs are keys to enhance regenerative health and improve patient care. Epigenetics represents one of the major biological mechanisms involving in tissue regeneration, and therefore can be viewed as a systemic (body-wide) control. However, how epigenetic regulations concertedly lead to the development of biological memories at the whole-body level remains unclear. Here, we review the evolving definitions of epigenetics and identify missing links. We then propose our Manifold Epigenetic Model (MEMo) as a conceptual framework to explain how epigenetic memory arises and discuss what strategies can be applied to manipulate the body-wide memory. In summary we provide a conceptual roadmap for the development of new engineering approaches to improve regenerative health.
尽管再生医学取得了令人鼓舞的进展，但仍迫切需要改进治疗方法。例如，延缓衰老和延长健康寿命是迫在眉睫的社会挑战。我们识别生物信号以及细胞与器官之间通讯的能力是增强再生健康和改善患者护理的关键。表观遗传学是涉及组织再生的主要生物学机制之一，因此可被视为一种全身性（全身范围）的调控。然而，表观遗传调控如何协同导致全身水平的生物记忆形成仍不清楚。在这里，我们回顾了表观遗传学不断演变的定义并找出缺失环节。然后我们提出我们的多组表观遗传模型（MEMo）作为一个概念框架来解释表观遗传记忆是如何产生的，并讨论可以应用哪些策略来操纵全身记忆。总之，我们为开发改善再生健康的新工程方法提供了一个概念路线图。
