Department of Anesthesiology, The Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, China.
Front Biosci (Landmark Ed). 2023 Feb 24;28(2):35. doi: 10.31083/j.fbl2802035.
Neuropathic pain is a chronic secondary pain condition resulting from lesions or diseases of the peripheral or central nervous system (CNS). Neuropathic pain is closely related to edema, inflammation, increased neuronal excitability, and central sensitization caused by glutamate accumulation. Aquaporins (AQPs), mainly responsible for the transport and clearance of water and solute, play important roles in developing CNS diseases, especially neuropathic pain. This review focuses on the interaction of AQPs with neuropathic pain, and the potential of AQPs, especially aquaporins 4, as therapeutic targets.
神经病理性疼痛是一种由外周或中枢神经系统（CNS）的损伤或疾病引起的慢性继发性疼痛状况。神经病理性疼痛与由谷氨酸积累引起的水肿、炎症、神经元兴奋性增加和中枢敏化密切相关。水通道蛋白（AQPs）主要负责水和溶质的运输和清除，在中枢神经系统疾病的发展中，特别是在神经病理性疼痛中发挥着重要作用。本综述重点介绍了 AQPs 与神经病理性疼痛的相互作用，以及 AQPs，特别是水通道蛋白 4，作为治疗靶点的潜力。
