Department of Nephrology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Department of Cell Biology, Center for Stem Cell and Medicine, Naval Medical University (Second Military Medical University), Shanghai, China.
Ren Fail. 2023 Dec;45(1):2183727. doi: 10.1080/0886022X.2023.2183727.
The association between vascular calcification (VC) and kidney stone is still inconclusive. Therefore, we conducted a meta-analysis to estimate the risk of kidney stone disease in subjects with VC.
To identify publications from related clinical studies, we performed a search on PubMed, Web of Science, Embase, and Cochrane Library databases from their inceptions until 1 September 2022. According to obvious heterogeneity, a random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Subgroup analysis was conducted trying to dissect the effects of VC in different segments and population regions in predicting kidney stone risk.
Seven articles were included with a total number of 69,135 patients, of which 10,052 have vascular calcifications and 4728 have kidney stones. There was a significantly higher risk of kidney stone disease in participants with VC versus control (OR = 1.54, 95% CI: 1.13-2.10). Sensitivity analysis confirmed the stability of the results. VC can be separated into abdominal, coronary, carotid, and splenic aortic calcification while pooled analysis of abdominal aorta calcification did not indicate a significant higher kidney stone risk. An obvious higher risk of kidney stone was observed in Asian VC patients (OR = 1.68, 95% CI: 1.07-2.61).
Combined evidence of observational studies suggested patients with VC may be associated with an increased risk of kidney stone disease. Despite the predictive value was relatively low, it is still worth noting that patients with VC are under the threat of kidney stone disease.
血管钙化（VC）与肾结石之间的关联仍不确定。因此，我们进行了一项荟萃分析，以评估 VC 患者发生肾结石病的风险。
为了确定与相关临床研究相关的出版物，我们在 PubMed、Web of Science、Embase 和 Cochrane Library 数据库中进行了检索，检索时间从数据库建立至 2022 年 9 月 1 日。根据明显的异质性，使用随机效应模型计算了比值比（ORs）及其相应的 95%置信区间（CIs）。进行了亚组分析，试图剖析 VC 在不同节段和人群地区预测肾结石风险中的作用。
共纳入 7 篇文章，总计 69135 例患者，其中 10052 例有血管钙化，4728 例有肾结石。与对照组相比，VC 患者发生肾结石病的风险显著更高（OR=1.54，95%CI：1.13-2.10）。敏感性分析证实了结果的稳定性。VC 可分为腹部、冠状动脉、颈动脉和脾主动脉钙化，而腹部主动脉钙化的汇总分析并未表明肾结石风险显著增加。亚洲 VC 患者的肾结石风险明显更高（OR=1.68，95%CI：1.07-2.61）。
观察性研究的综合证据表明，VC 患者可能与肾结石病风险增加相关。尽管预测值相对较低，但仍值得注意的是，VC 患者存在肾结石病的威胁。
