Abedi Amir Reza, Montazeri Saeed, Sanei Taheri Morteza, Hojjati Seyyed Ali, Fallah-Karkan Morteza, Soleimani Reza, Alinejad Khorram Amir
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urology and Nephrology Research Center (UNRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2024 Oct 7;38:115. doi: 10.47176/mjiri.38.115. eCollection 2024.
Nephrolithiasis is a common condition that has been linked to various systemic diseases. Recent studies have suggested that young patients with nephrolithiasis are at increased risk of developing premature atherosclerosis. This study aims to investigate the relationship between nephrolithiasis and systemic disease by examining the association between aortic calcification and the severity of kidney stone disease.
This study employed a matched case-control design involving 144 patients with kidney stones and 144 non-stone formers. All participants underwent non-contrast abdominal and pelvic CT scans. The Agatston score was used to quantify the severity of aortic calcification. The data were analyzed and compared between the two groups. Quantitative data were analyzed using Pearson's chi-square test. Non-parametric data were analyzed using the Mann-Whitney test.
The Agatston score was measured in both case and control groups, with mean values of 316±734 and 231±706, respectively. However, the difference between the two groups was not statistically significant ( = 0.122). Notably, a significant correlation was observed between Agatston score and stone size ( = 0.014). The value of the correlation coefficient is 0.23, which shows the increase in severity of aortic calcification with increasing stone size. A comparison of the Agatston score between male kidney stone formers patients aged 45 years or younger and controls revealed a statistically significant difference, with a p-value of 0.049, indicating more pronounced aortic calcification in the patient group.
These results suggest that there may be a shared pathophysiological mechanism underlying both nephrolithiasis and atherosclerosis.
肾结石是一种常见疾病，与多种全身性疾病有关。最近的研究表明，患有肾结石的年轻患者发生过早动脉粥样硬化的风险增加。本研究旨在通过检查主动脉钙化与肾结石疾病严重程度之间的关联，来探讨肾结石与全身性疾病之间的关系。
本研究采用匹配病例对照设计，纳入144例肾结石患者和144例非结石形成者。所有参与者均接受了非增强腹部和盆腔CT扫描。使用阿加斯顿评分来量化主动脉钙化的严重程度。对两组数据进行分析和比较。定量数据采用Pearson卡方检验进行分析。非参数数据采用Mann-Whitney检验进行分析。
对病例组和对照组均测量了阿加斯顿评分，其平均值分别为316±734和231±706。然而，两组之间的差异无统计学意义（=0.122）。值得注意的是，观察到阿加斯顿评分与结石大小之间存在显著相关性（=0.014）。相关系数的值为0.23，表明随着结石大小增加，主动脉钙化严重程度增加。对45岁及以下男性肾结石患者与对照组的阿加斯顿评分进行比较，发现差异具有统计学意义，p值为0.049，表明患者组的主动脉钙化更为明显。
这些结果表明，肾结石和动脉粥样硬化可能存在共同的病理生理机制。
